Metal-Organic Framework-Based Nanomedicine Platforms for Drug Delivery and Molecular Imaging

被引：456

作者：

Cai, Wen ^{[1
,2
,3
]}

Chu, Cheng-Chao ^{[1
,2
]}

Liu, Gang ^{[1
,2
]}

Wang, Yi-Xiang J. ^{[3
]}

机构：

[1] Xiamen Univ, State Key Lab Mol Vaccinol & Mol Diagnost, Sch Publ Hlth, Xiamen 361102, Peoples R China

[2] Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, Xiamen 361102, Peoples R China

[3] Chinese Univ Hong Kong, Dept Imaging & Intervent Radiol, Prince Wales Hosp, Shatin, Hong Kong, Peoples R China

来源：

SMALL | 2015年 / 11卷 / 37期

基金：

中国国家自然科学基金;

关键词：

ZEOLITIC IMIDAZOLATE FRAMEWORK-8; IRON-OXIDE NANOPARTICLES; NANOSCALE COORDINATION POLYMERS; CONTRAST-AGENTS; ULTRASONIC SYNTHESIS; MICROWAVE SYNTHESIS; FACILE SYNTHESIS; CRYSTAL-GROWTH; ONE-STEP; GADOLINIUM;

D O I：

10.1002/smll.201500802

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Metal-organic frameworks (MOFs), which are a unique class of hybrid porous materials built from metal ions and organic linkers, have attracted significant research interest in recent years. Compared with conventional porous materials, MOFs exhibit a variety of advantages, including a large surface area, a tunable pore size and shape, an adjustable composition and structure, biodegradability, and versatile functionalities, which enable MOFs to perform as promising platforms for drug delivery, molecular imaging, and theranostic applications. In this article, the recent research progress related to nanoscale metal-organic frameworks (NMOFs) is summarized with a focus on synthesis strategies and drug delivery, molecular imaging, and theranostic applications. The future challenges and opportunities of NMOFs are also discussed in the context of translational medical research. More effort is warranted to develop clinically translatable NMOFs for various applications in nanomedicine.

引用

页码：4806 / 4822

页数：17

共 139 条

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