Cation-Triggered Drug Release from a Porous Zinc-Adeninate Metal-Organic Framework

被引：948

作者：

An, Jihyun ^{[1
]}

Geib, Steven J. ^{[1
]}

Rosi, Nathaniel L. ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 24期

关键词：

SECONDARY BUILDING UNITS; COORDINATION POLYMERS; DELIVERY; PROCAINAMIDE; SOLIDS; DESIGN; SYSTEM; AGENTS;

D O I：

10.1021/ja902972w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A porous anionic metal-organic framework, bio-MOF-1, constructed using adenine as a biomolecular building block is described. The porosity of this material is evaluated, its stability in biological buffers is studied, and its potential as a material for controlled drug release is investigated. Specifically, procainamide HCl is loaded into the pores of bio-MOF-1 using a simple cation exchange process. Exogenous cations from biological buffers are shown to affect the release of the adsorbed drug molecules.

引用

收藏

页码：8376 / +

页数：3

相关论文

共 23 条

[1] Chiral three-dimensional microporous nickel aspartate with extended Ni-O-Ni bonding [J].

Anokhina, Ekaterina V. ;

Go, Yong Bok ;

Lee, Yongjae ;

Vogt, Thomas ;

Jacobson, Allan J. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (30) :9957-9962

[2] Modular chemistry: Secondary building units as a basis for the design of highly porous and robust metal-organic carboxylate frameworks [J].

Eddaoudi, M ;

Moler, DB ;

Li, HL ;

Chen, BL ;

Reineke, TM ;

O'Keeffe, M ;

Yaghi, OM .

ACCOUNTS OF CHEMICAL RESEARCH, 2001, 34 (04) :319-330

[3] Hybrid porous solids:: past, present, future [J].

Ferey, Gerard .

CHEMICAL SOCIETY REVIEWS, 2008, 37 (01) :191-214

[4] An unusual 3D coordination polymer based on bridging interactions of the nucleobase adenine [J].

García-Terán, JP ;

Castillo, O ;

Luque, A ;

García-Couceiro, U ;

Román, P ;

Lezama, L .

INORGANIC CHEMISTRY, 2004, 43 (15) :4549-4551

[5] Stimuli-responsive controlled-release delivery system based on mesoporous silica nanorods capped with magnetic nanoparticles [J].

Giri, S ;

Trewyn, BG ;

Stellmaker, MP ;

Lin, VSY .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (32) :5038-5044

[6] Flexible porous metal-organic frameworks for a controlled drug delivery [J].

Horcajada, Patricia ;

Serre, Christian ;

Maurin, Guillaume ;

Ramsahye, Naseem A. ;

Balas, Francisco ;

Vallet-Regi, Maria ;

Sebban, Muriel ;

Taulelle, Francis ;

Ferey, Gerard .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (21) :6774-6780

[7] Metal-organic frameworks as efficient materials for drug delivery [J].

Horcajada, Patricia ;

Serre, Christian ;

Vallet-Regi, Maria ;

Sebban, Muriel ;

Taulelle, Francis ;

Ferey, Gerard .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (36) :5974-5978

[8] Activity of Procanbid(R), procainamide twice-daily formulation, to suppress ventricular premature depolarizations [J].

Kerin, NZ ;

Meengs, WL ;

Timmis, GC ;

Salerno, D ;

Haber, HE ;

Singer, RM ;

Switzer, D ;

Zoble, R ;

Carlson, M ;

Weidler, D ;

Raghavan, P ;

Schwartz, K ;

Somberg, JC ;

Kereiakes, D ;

Ellenbogen, KA .

CARDIOVASCULAR DRUGS AND THERAPY, 1997, 11 (02) :169-175

[9] Functional porous coordination polymers [J].

Kitagawa, S ;

Kitaura, R ;

Noro, S .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (18) :2334-2375

[10] PROCAINAMIDE DOSAGE SCHEDULES, PLASMA CONCENTRATIONS, AND CLINICAL EFFECTS [J].

KOCHWESER, J ;

KLEIN, SW .

JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1971, 215 (09) :1454-+