Metal-organic frameworks as efficient materials for drug delivery

被引：1829

作者：

Horcajada, Patricia

Serre, Christian

Vallet-Regi, Maria

Sebban, Muriel

Taulelle, Francis

Ferey, Gerard

机构：

[1] Univ Versailles, CNRS, UMR 8180, Inst Lavoisier, F-78035 Versailles, France

[2] Univ Complutense Madrid, Fac Farm, Dept Quim Inorgan & Bioinorgan, E-28040 Madrid, Spain

[3] Tectospin Grp, Inst Lavoisier, Versailles, France

[4] NMRtec, Versailles, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 36期

关键词：

controlled delivery; drug delivery; hybrid materials; porous materials;

D O I：

10.1002/anie.200601878

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Fill 'em up: The metal carboxylates MIL-100 and MIL-101 act as porous matrices (see picture; MIL = Materials of Institut Lavoisier) for drug-delivery systems using Ibuprofen as a model substrate. Very large amounts of the drug could be incorporated, up to an unprecedented capacity of 1.4 g of drug per gram of porous solid for MIL-101, and the total release of Ibuprofen was achieved under physiological conditions in 3 (MIL-100) and 6 days (MIL-101). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5974 / 5978

页数：5

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