Extracellular Vesicle-Based Hydrogels for Wound Healing Applications

被引：23

作者：

Amengual-Tugores, Andreu Miquel ^{[1
,2
]}

Raez-Meseguer, Carmen ^{[1
,2
]}

Forteza-Genestra, Maria Antonia ^{[1
,2
]}

Monjo, Marta ^{[1
,2
,3
]}

Ramis, Joana M. ^{[1
,2
,3
]}

机构：

[1] Univ Balear Isl UIB, Res Inst Hlth Sci IUNICS, Cell Therapy & Tissue Engn Grp, Ctra Valldemossa Km 7-5, Palma De Mallorca 07122, Spain

[2] Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca 07120, Spain

[3] Univ Balear Isl UIB, Dept Biol Fonamental & Ciencies Salut, Palma De Mallorca 07122, Spain

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 04期

关键词：

extracellular vesicles; exosomes; biomaterials; hydrogels; wound healing; EXOSOMES; NANOPARTICLES; NEUTROPHILS; BIOGENESIS; NANOFIBERS; MANAGEMENT; RELEASE; PROMOTE; CARE;

D O I：

10.3390/ijms24044104

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Hydrogels and extracellular vesicle-based therapies have been proposed as emerging therapeutic assets in wound closure. The combination of these elements has given good results in managing chronic and acute wounds. The intrinsic characteristics of the hydrogels in which the extracellular vesicles (EVs) are loaded allow for overcoming barriers, such as the sustained and controlled release of EVs and the maintenance of the pH for their conservation. In addition, EVs can be obtained from different sources and through several isolation methods. However, some barriers must be overcome to transfer this type of therapy to the clinic, for example, the production of hydrogels containing functional EVs and identifying long-term storage conditions for EVs. The aim of this review is to describe the reported EV-based hydrogel combinations, along with the obtained results, and analyze future perspectives.

引用

页数：16

共 97 条

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