The role of lactate in cardiovascular diseases

被引：76

作者：

Ouyang, Jun ^{[1
]}

Wang, Hui ^{[2
]}

Huang, Jiangnan ^{[1
]}

机构：

[1] Guangxi Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanning, Peoples R China

[2] Guangxi Med Univ, Sch Pharm, Nanning, Peoples R China

来源：

CELL COMMUNICATION AND SIGNALING | 2023年 / 21卷 / 01期

关键词：

Lactate; Lactylation; Acute myocardial infarction; Heart failure; Atrial fibrillation; Atherosclerosis; MONOCARBOXYLATE TRANSPORTER MCT1; ATRIAL-FIBRILLATION; HEART-FAILURE; BLOOD LACTATE; AEROBIC GLYCOLYSIS; ADIPOSE-TISSUE; UP-REGULATION; METABOLISM; CANCER; MITOCHONDRIAL;

D O I：

10.1186/s12964-023-01350-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Cardiovascular diseases pose a major threat worldwide. Common cardiovascular diseases include acute myocardial infarction (AMI), heart failure, atrial fibrillation (AF) and atherosclerosis. Glycolysis process often has changed during these cardiovascular diseases. Lactate, the end-product of glycolysis, has been overlooked in the past but has gradually been identified to play major biological functions in recent years. Similarly, the role of lactate in cardiovascular disease is gradually being recognized. Targeting lactate production, regulating lactate transport, and modulating circulating lactate levels may serve as potential strategies for the treatment of cardiovascular diseases in the future. The purpose of this review is to integrate relevant clinical and basic research on the role of lactate in the pathophysiological process of cardiovascular disease in recent years to clarify the important role of lactate in cardiovascular disease and to guide further studies exploring the role of lactate in cardiovascular and other diseases.3qAqkYngHfGCLT3NwvMPZ7Video Abstract

引用

页数：14

共 182 条

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