The role of lactate in cardiovascular diseases

被引：76

作者：

Ouyang, Jun ^{[1
]}

Wang, Hui ^{[2
]}

Huang, Jiangnan ^{[1
]}

机构：

[1] Guangxi Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanning, Peoples R China

[2] Guangxi Med Univ, Sch Pharm, Nanning, Peoples R China

来源：

CELL COMMUNICATION AND SIGNALING | 2023年 / 21卷 / 01期

关键词：

Lactate; Lactylation; Acute myocardial infarction; Heart failure; Atrial fibrillation; Atherosclerosis; MONOCARBOXYLATE TRANSPORTER MCT1; ATRIAL-FIBRILLATION; HEART-FAILURE; BLOOD LACTATE; AEROBIC GLYCOLYSIS; ADIPOSE-TISSUE; UP-REGULATION; METABOLISM; CANCER; MITOCHONDRIAL;

D O I：

10.1186/s12964-023-01350-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Cardiovascular diseases pose a major threat worldwide. Common cardiovascular diseases include acute myocardial infarction (AMI), heart failure, atrial fibrillation (AF) and atherosclerosis. Glycolysis process often has changed during these cardiovascular diseases. Lactate, the end-product of glycolysis, has been overlooked in the past but has gradually been identified to play major biological functions in recent years. Similarly, the role of lactate in cardiovascular disease is gradually being recognized. Targeting lactate production, regulating lactate transport, and modulating circulating lactate levels may serve as potential strategies for the treatment of cardiovascular diseases in the future. The purpose of this review is to integrate relevant clinical and basic research on the role of lactate in the pathophysiological process of cardiovascular disease in recent years to clarify the important role of lactate in cardiovascular disease and to guide further studies exploring the role of lactate in cardiovascular and other diseases.3qAqkYngHfGCLT3NwvMPZ7Video Abstract

引用

页数：14

共 182 条

[21]

Lung Myofibroblasts Promote Macrophage Profibrotic Activity through Lactate-induced Histone Lactylation [J].

Cui, Huachun ;

Xie, Na ;

Banerjee, Sami ;

Ge, Jing ;

Jiang, Dingyuan ;

Dey, Tapan ;

Matthews, Qiana L. ;

Liu, Rui-Ming ;

Liu, Gang .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2021, 64 (01) :115-125

[22]

Dynamic profiling and functional interpretation of histone lysine crotonylation and lactylation during neural development [J].

Dai, Shang-Kun ;

Liu, Pei-Pei ;

Li, Xiao ;

Jiao, Lin-Fei ;

Teng, Zhao-Qian ;

Liu, Chang-Mei .

DEVELOPMENT, 2022, 149 (14)

[23]

Histone lactylation: epigenetic mark of glycolytic switch [J].

Dai, Xiaofeng ;

Lv, Xinyu ;

Thompson, Erik W. ;

Ostrikov, Kostya .

TRENDS IN GENETICS, 2022, 38 (02) :124-127

[24]

Temporal Trends in Predictors of Early and Late Mortality After Emergency Coronary Artery Bypass Grafting for Cardiogenic Shock Complicating Acute Myocardial Infarction [J].

Davierwala, Piroze M. ;

Leontyev, Sergey ;

Verevkin, Alexander ;

Rastan, Ardawan J. ;

Mohr, Matthias ;

Bakhtiary, Farhad ;

Misfeld, Martin ;

Mohr, Friedrich W. .

CIRCULATION, 2016, 134 (17) :1224-+

[25]

Lactate Elicits ER-Mitochondrial Mg2+ Dynamics to Integrate Cellular Metabolism [J].

Daw, Cassidy C. ;

Ramachandran, Karthik ;

Enslow, Benjamin T. ;

Maity, Soumya ;

Bursic, Brian ;

Novello, Matthew J. ;

Rubannelsonkumar, Cherubina S. ;

Mashal, Ayah H. ;

Ravichandran, Joel ;

Bakewell, Terry M. ;

Wang, Weiwei ;

Li, Kang ;

Madaris, Travis R. ;

Shannon, Christopher E. ;

Norton, Luke ;

Kandala, Soundarya ;

Caplan, Jeffrey ;

Srikantan, Subramanya ;

Stathopulos, Peter B. ;

Reeves, W. Brian ;

Madesh, Muniswamy .

CELL, 2020, 183 (02) :474-+

[26]

D-lactate transport and metabolism in rat liver mitochondria [J].

de Bari, L ;

Atlante, A ;

Guaragnella, N ;

Principato, G ;

Passarella, S .

BIOCHEMICAL JOURNAL, 2002, 365 (02) :391-403

[27]

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting [J].

De Bock, Katrien ;

Georgiadou, Maria ;

Schoors, Sandra ;

Kuchnio, Anna ;

Wong, Brian W. ;

Cantelmo, Anna Rita ;

Quaegebeur, Annelies ;

Ghesquiere, Bart ;

Cauwenberghs, Sandra ;

Eelen, Guy ;

Phng, Li-Kun ;

Betz, Inge ;

Tembuyser, Bieke ;

Brepoels, Katleen ;

Welti, Jonathan ;

Geudens, Ilse ;

Segura, Inmaculada ;

Cruys, Bert ;

Bifari, Franscesco ;

Decimo, Ilaria ;

Blanco, Raquel ;

Wyns, Sabine ;

Vangindertael, Jeroen ;

Rocha, Susana ;

Collins, Russel T. ;

Munck, Sebastian ;

Daelemans, Dirk ;

Imamura, Hiromi ;

Devlieger, Roland ;

Rider, Mark ;

Van Veldhoven, Paul P. ;

Schuit, Frans ;

Bartrons, Ramon ;

Hofkens, Johan ;

Fraisl, Peter ;

Telang, Sucheta ;

DeBerardinis, Ralph J. ;

Schoonjans, Luc ;

Vinckier, Stefan ;

Chesney, Jason ;

Gerhardt, Holger ;

Dewerchin, Mieke ;

Carmeliet, Peter .

CELL, 2013, 154 (03) :651-663

[28]

Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis [J].

DeBerardinis, Ralph J. ;

Mancuso, Anthony ;

Daikhin, Evgueni ;

Nissim, Ilana ;

Yudkoff, Marc ;

Wehrli, Suzanne ;

Thompson, Craig B. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (49) :19345-19350

[29]

LACTATE PRODUCTION IN ADIPOSE-TISSUE - A REGULATED FUNCTION WITH EXTRA-ADIPOSE IMPLICATIONS [J].

DIGIROLAMO, M ;

NEWBY, FD ;

LOVEJOY, J .

FASEB JOURNAL, 1992, 6 (07) :2405-2412

[30]

The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells [J].

Dimmer, KS ;

Friedrich, B ;

Lang, F ;

Deitmer, JW ;

Bröer, S .

BIOCHEMICAL JOURNAL, 2000, 350 :219-227

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