Macrophages in the process of osseointegration around the implant and their regulatory strategies

被引：10

作者：

Fang, Xin ^{[1
]}

Sun, Duo ^{[1
]}

Li, Yongli ^{[1
]}

Han, Xiao ^{[1
]}

Gan, Yulu ^{[1
]}

Jiao, Junjie ^{[1
]}

Jiang, Mengyuan ^{[1
]}

Gong, Heyi ^{[1
]}

Qi, Yuanzheng ^{[1
]}

Zhao, Jinghui ^{[1
,2
]}

机构：

[1] Jilin Univ, Hosp Stomatol, Dept Dent Implantol, Qinghua Rd 1500, Changchun 130021, Jilin, Peoples R China

[2] Jilin Univ, Hosp Stomatol, Jilin Prov Key Lab Tooth Dept & Bone Remodeling, Changchun, Jilin, Peoples R China

来源：

CONNECTIVE TISSUE RESEARCH | 2024年 / 65卷 / 01期

关键词：

Macrophage; osteointegration; osteoimmunity; regulation; implant; BONE-FORMATION; ACTIVATION; DIFFERENTIATION; POLARIZATION; TOPOGRAPHY; SURFACE; REPAIR; CELLS; VEGF; REGENERATION;

D O I：

10.1080/03008207.2023.2300455

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Purpose/Aim of the studyTo summarize and discuss macrophage properties and their roles and mechanisms in the process of osseointegration in a comprehensive manner, and to provide theoretical support and research direction for future implant surface modification efforts.Materials and methodsBased on relevant high-quality articles, this article reviews the role of macrophages in various stages of osseointegration and methods of implant modification.Results and conclusionsMacrophages not only promote osseointegration through immunomodulation, but also secrete a variety of cytokines, which play a key role in the angiogenic and osteogenic phases of osseointegration. There is no "good" or "bad" difference between the M1 and M2 phenotypes of macrophages, but their timely presence and sequential switching play a crucial role in implant osseointegration. In the implant surface modification strategy, the induction of sequential activation of the M1 and M2 phenotypes of macrophages is a brighter prospect for implant surface modification than inducing the polarization of macrophages to the M1 or M2 phenotypes individually, which is a promising pathway to enhance the effect of osseointegration and increase the success rate of implant surgery.

引用

页码：1 / 15

页数：15

共 97 条

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