Biological Macromolecule-Based Scaffolds for Urethra Reconstruction

被引：7

作者：

Farzamfar, Saeed ^{[1
]}

Richer, Megan ^{[1
]}

Rahmani, Mahya ^{[2
]}

Naji, Mohammad ^{[3
]}

Aleahmad, Mehdi ^{[4
]}

Chabaud, Stephane ^{[1
]}

Bolduc, Stephane ^{[1
,5
]}

机构：

[1] Univ Laval, Ctr Rech Organogenese Expt LOEX, Regenerat Med Div, CHU Quebec,Res Ctr, Quebec City, PQ G1V 4G2, Canada

[2] Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Dept Tissue Engn & Appl Cell Sci, Tehran 1983963113, Iran

[3] Shahid Beheshti Univ Med Sci, Urol & Nephrol Res Ctr, Tehran 1983963113, Iran

[4] Univ Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Tehran 1417613151, Iran

[5] Laval Univ, Fac Med, Dept Surg, Quebec City, PQ G1V 0A6, Canada

来源：

BIOMOLECULES | 2023年 / 13卷 / 08期

关键词：

biological macromolecules; urethra reconstruction; tissue engineering; urethra defects; HYALURONIC-ACID HYDROGELS; FIBROIN/COLLAGEN ELECTROSPUN FIBER; SEEDED TUBULARIZED SCAFFOLDS; SMALL-INTESTINE SUBMUCOSA; BACTERIAL CELLULOSE; MECHANICAL-PROPERTIES; COLLAGEN SCAFFOLDS; DRUG-DELIVERY; EXTRACELLULAR-MATRIX; INTERNAL URETHROTOMY;

D O I：

10.3390/biom13081167

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Urethral reconstruction strategies are limited with many associated drawbacks. In this context, the main challenge is the unavailability of a suitable tissue that can endure urine exposure. However, most of the used tissues in clinical practices are non-specialized grafts that finally fail to prevent urine leakage. Tissue engineering has offered novel solutions to address this dilemma. In this technology, scaffolding biomaterials characteristics are of prime importance. Biological macromolecules are naturally derived polymers that have been extensively studied for various tissue engineering applications. This review discusses the recent advances, applications, and challenges of biological macromolecule-based scaffolds in urethral reconstruction.

引用

页数：23

共 194 条

[1]

Scaffolding polymeric biomaterials: Are naturally occurring biological macromolecules more appropriate for tissue engineering? [J].