Role of Exosomes in Epithelial-Mesenchymal Transition

被引：26

作者：

Bhattacharya, Bikramjit ^{[1
]}

Nag, Sagnik ^{[2
]}

Mukherjee, Sayantanee ^{[3
]}

Kulkarni, Mrunal ^{[4
]}

Chandane, Priti ^{[5
]}

Mandal, Debashmita ^{[6
]}

Mukerjee, Nobendu ^{[7
,8
]}

Mirgh, Divya ^{[9
]}

Anand, Krishnan ^{[10
]}

Adhikari, Manab Deb ^{[11
]}

Gorai, Sukhamoy ^{[12
]}

Thorat, Nanasaheb ^{[13
,14
]}

机构：

[1] Vellore Inst Technol VIT, Sch Biosci & Technol, Dept Appl Microbiol, Vellore 632014, Tamil Nadu, India

[2] Vellore Inst Technol VIT, Sch Biosci & Technol, Dept Biosci, Tiruvalam Rd, Vellore 632014, Tamil Nadu, India

[3] Amrita Inst Med Sci, Amrita Sch Nanosci & Mol Med, Kochi 682041, Kerala, India

[4] BITS Pilani, Dept Pharm, Pilani 333031, Rajasthan, India

[5] Univ Hyderabad, Dept Biochem, Hyderabad 500046, India

[6] Maulana Abul Kalam Azad Univ Technol MAKAUT, Dept Biotechnol, Nadia 741249, W Bengal, India

[7] Saveetha Med Coll & Hosp, Saveetha Inst Med & Tech Sci, Ctr Global Hlth Res, Chennai 600077, Tamil Nadu, India

[8] Novel Global Community Educ Fdn, Dept Hlth Sci, Hebersham, NSW 2770, Australia

[9] Massachusetts Gen Hosp, Vaccine & Immunotherapy Canter, Boston, MA 02114 USA

[10] Univ Free State, Fac Hlth Sci, Sch Pathol, Dept Chem Pathol, ZA-9300 Bloemfontein, South Africa

[11] Univ North Bengal Raja Rammohunpur, Dept Biotechnol, Darjeeling 734013, W Bengal, India

[12] Rush Univ, Med Ctr, Chicago, IL 60612 USA

[13] Univ Limerick, Bernal Inst, Limerick Digital Canc Res Ctr, Limerick V94T9PX, Ireland

[14] Univ Limerick, Dept Phys, Limerick V94T9PX, Ireland

来源：

ACS APPLIED BIO MATERIALS | 2023年 / 7卷 / 01期

基金：

爱尔兰科学基金会;

关键词：

Exosome; Cancer; Metastasis; EMT; Biomarkers; Therapeutic; EXTRACELLULAR VESICLES; NASOPHARYNGEAL CARCINOMA; CANCER STATISTICS; METASTASIS; CELLS; MATRIX; BIOMARKER; COLONIZATION; REGULATORS; PRINCIPLES;

D O I：

10.1021/acsabm.3c00941

中图分类号：

TB3 [工程材料学];

学科分类号：

082905 [生物质能源与材料];

摘要：

Epithelial-mesenchymal transition (EMT) is a fundamental process driving cancer metastasis, transforming non-motile cells into a motile population that migrates to distant organs and forms secondary tumors. In recent years, cancer research has revealed a strong connection between exosomes and the EMT. Exosomes, a subpopulation of extracellular vesicles, facilitate cellular communication and dynamically regulate various aspects of cancer metastasis, including immune cell suppression, extracellular matrix remodeling, metastasis initiation, EMT initiation, and organ-specific metastasis. Tumor-derived exosomes (TEXs) and their molecular cargo, comprising proteins, lipids, nucleic acids, and carbohydrates, are essential components that promote EMT in cancer. TEXs miRNAs play a crucial role in reprogramming the tumor microenvironment, while TEX surface integrins contribute to organ-specific metastasis. Exosome-based cancer metastasis research offers a deeper understanding about cancer and an effective theranostic platform development. Additionally, various therapeutic sources of exosomes are paving the way for innovative cancer treatment development. In this Review, we spotlight the role of exosomes in EMT and their theranostic impact, aiming to inspire cancer researchers worldwide to explore this fascinating field in more innovative ways.

引用

页码：44 / 58

页数：15

共 162 条

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