A review of expression profiling of circulating microRNAs in men with prostate cancer

被引：27

作者：

Kelly, Brian D. ^{[1
,2
]}

Miller, Nicola ^{[1
]}

Healy, Nuala A. ^{[1
]}

Walsh, Kilian ^{[2
]}

Kerin, Michael J. ^{[1
]}

机构：

[1] Natl Univ Ireland Galway, Discipline Surg, Inst Clin Sci, Galway, Ireland

[2] Galway Univ Hosp, Dept Urol, Galway, Ireland

来源：

BJU INTERNATIONAL | 2013年 / 111卷 / 01期

关键词：

miRNA; circulation; prostate cancer; DOWN-REGULATION; BIOMARKERS; GENES; RNA; SIGNATURES; MIR-141; MIRNAS; SERUM;

D O I：

10.1111/j.1464-410X.2012.11244.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

100201 [内科学]; 100221 [泌尿外科学];

摘要：

MicroRNAs (miRNAs) are small non-coding RNAs that are involved in gene regulation and expression. These molecules have been implicated in the pathogenesis of several malignancies. MiRNAs have the potential to be both a tissue-and blood-based biomarker for cancer diagnosis, classification, prognosis and response to treatment. The levels of dysregulated miRNAs in the circulation of individuals make miRNAs an ideal biomarker for the detection of prostate cancer. The present study provides a comprehensive review of the expression profiling of miRNAs in the circulation of men with prostate cancer. Further research is necessary to identify if circulating miRNAs have the potential to be a biomarker for prostate cancer in clinical practice.

引用

页码：17 / 21

页数：5

共 38 条

[11]

Circulating miRNA Signatures: Promising Prognostic Tools for Cancer [J].

Heneghan, Helen M. ;

Miller, Nicola ;

Kerin, Michael J. .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (29) :E573-E574

[12]

Systemic miRNA-195 Differentiates Breast Cancer from Other Malignancies and Is a Potential Biomarker for Detecting Noninvasive and Early Stage Disease [J].

Heneghan, Helen M. ;

Miller, Nicola ;

Kelly, Ronan ;

Newell, John ;

Kerin, Michael J. .

ONCOLOGIST, 2010, 15 (07) :673-682

[13]

Circulating microRNAs as Novel Minimally Invasive Biomarkers for Breast Cancer [J].

Heneghan, Helen M. ;

Miller, Nicola ;

Lowery, Aoife J. ;

Sweeney, Karl J. ;

Newell, John ;

Kerin, Michael J. .

ANNALS OF SURGERY, 2010, 251 (03) :499-505

[14]

Detection of microRNA Expression in Human Peripheral Blood Microvesicles [J].

Hunter, Melissa Piper ;

Ismail, Noura ;

Zhang, Xiaoli ;

Aguda, Baltazar D. ;

Lee, Eun Joo ;

Yu, Lianbo ;

Xiao, Tao ;

Schafer, Jeffrey ;

Lee, Mei-Ling Ting ;

Schmittgen, Thomas D. ;

Nana-Sinkam, S. Patrick ;

Jarjoura, David ;

Marsh, Clay B. .

PLOS ONE, 2008, 3 (11)

[15]

MicroRNA gene expression deregulation in human breast cancer [J].

Iorio, MV ;

Ferracin, M ;

Liu, CG ;

Veronese, A ;

Spizzo, R ;

Sabbioni, S ;

Magri, E ;

Pedriali, M ;

Fabbri, M ;

Campiglio, M ;

Ménard, S ;

Palazzo, JP ;

Rosenberg, A ;

Musiani, P ;

Volinia, S ;

Nenci, I ;

Calin, GA ;

Querzoli, P ;

Negrini, M ;

Croce, CM .

CANCER RESEARCH, 2005, 65 (16) :7065-7070

[16]

MicroRNA genes are transcribed by RNA polymerase II [J].

Lee, Y ;

Kim, M ;

Han, JJ ;

Yeom, KH ;

Lee, S ;

Baek, SH ;

Kim, VN .

EMBO JOURNAL, 2004, 23 (20) :4051-4060

[17]

Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets [J].

Lewis, BP ;

Burge, CB ;

Bartel, DP .

CELL, 2005, 120 (01) :15-20

[18]

Exploiting salivary miR-31 as a clinical biomarker of oral squamous cell carcinoma [J].

Liu, Chung-Ji ;

Lin, Shu-Chun ;

Yang, Cheng-Chieh ;

Cheng, Hui-Wen ;

Chang, Kuo-Wei .

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2012, 34 (02) :219-224

[19]

Detection of Cancer with Serum miRNAs on an Oligonucleotide Microarray [J].

Lodes, Michael J. ;

Caraballo, Marcelo ;

Suciu, Dominic ;

Munro, Sandra ;

Kumar, Amit ;

Anderson, Brooke .

PLOS ONE, 2009, 4 (07)

[20]

MicroRNA expression profiles classify human cancers [J].

Lu, J ;

Getz, G ;

Miska, EA ;

Alvarez-Saavedra, E ;

Lamb, J ;

Peck, D ;

Sweet-Cordero, A ;

Ebet, BL ;

Mak, RH ;

Ferrando, AA ;

Downing, JR ;

Jacks, T ;

Horvitz, HR ;

Golub, TR .

NATURE, 2005, 435 (7043) :834-838

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