Oral use of interferon

被引:36
作者
Cummins, JM
Beilharz, MW
Krakowka, S
机构
[1] Amarillo Biosci Inc, Amarillo, TX 79101 USA
[2] Univ Western Australia, Queen Elizabeth II Med Ctr, Dept Microbiol, Nedlands, WA 6009, Australia
[3] Ohio State Univ, Coll Vet Med, Dept Vet Biosci, Columbus, OH 43210 USA
关键词
D O I
10.1089/107999099313352
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Interferon-alpha (IFN-alpha) given orally has biological activity in humans and other animals. The dose providing the most benefit delivers IFN-alpha to the oral mucosa in a concentration (10(2)-10(3) IU), similar to that naturally produced in the nasal secretions during respiratory infections. In contrast, conventional IFN therapy employs parenteral doses of >10(6) IU and, for this reason, orally administered IFN therapies have been called low-dose treatments. Efficacy in both animal disease models and human studies has been reported, and the mechanisms whereby oral administration has a systemic effect are under active study in a number of laboratories.
引用
收藏
页码:853 / 857
页数:5
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