Temporal Dynamics of the Human Vaginal Microbiota

被引：1004

作者：

Gajer, Pawel

Brotman, Rebecca M.

Bai, Guoyun

Sakamoto, Joyce

Schuette, Ursel M. E.

Zhong, Xue

Koenig, Sara S. K.

Fu, Li

Ma, Zhanshan

Zhou, Xia

Abdo, Zaid

Forney, Larry J.

Ravel, Jacques

机构：

[1] Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore

[2] Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore

[3] Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore

[4] Department of Biological Sciences, University of Idaho, Moscow

[5] Institute for Bioinformatics and Evolutionary Studies, University of Idaho, Moscow

[6] Department of Mathematics, University of Idaho, Moscow

[7] Department of Statistics, University of Idaho, Moscow

[8] Center for Infectious Disease Dynamics, Huck Institutes for the Life Sciences, Pennsylvania State University, University Park

[9] School of Public and Environmental Affairs, Indiana University, Bloomington

[10] Vanderbilt Center for Quantitative Sciences, Vanderbilt University, Nashville

[11] State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2012年 / 4卷 / 132期

关键词：

D O I：

10.1126/scitranslmed.3003605

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Elucidating the factors that impinge on the stability of bacterial communities in the vagina may help in predicting the risk of diseases that affect women's health. Here, we describe the temporal dynamics of the composition of vaginal bacterial communities in 32 reproductive-age women over a 16-week period. The analysis revealed the dynamics of five major classes of bacterial communities and showed that some communities change markedly over short time periods, whereas others are relatively stable. Modeling community stability using new quantitative measures indicates that deviation from stability correlates with time in the menstrual cycle, bacterial community composition, and sexual activity. The women studied are healthy; thus, it appears that neither variation in community composition per se nor higher levels of observed diversity (co-dominance) are necessarily indicative of dysbiosis.

引用

页数：1

共 35 条

[21] RELIABILITY OF DIAGNOSING BACTERIAL VAGINOSIS IS IMPROVED BY A STANDARDIZED METHOD OF GRAM STAIN INTERPRETATION
NUGENT, RP
KROHN, MA
HILLIER, SL
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1991, 29 (02) : 297 - 301
[22] Pinheiro JC., 2006, NLME LINEAR NONLINEA
[23] Vaginal microbiome of reproductive-age women
Ravel, Jacques
Gajer, Pawel
Abdo, Zaid
Schneider, G. Maria
Koenig, Sara S. K.
McCulle, Stacey L.
Karlebach, Shara
Gorle, Reshma
Russell, Jennifer
Tacket, Carol O.
Brotman, Rebecca M.
Davis, Catherine C.
Ault, Kevin
Peralta, Ligia
Forney, Larry J.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 : 4680 - 4687
[24] Correlation of behaviors with microbiological changes in vaginal flora
Schwebke, JR
Richey, CM
Weiss, HL
[J]. JOURNAL OF INFECTIOUS DISEASES, 1999, 180 (05) : 1632 - 1636
[25] Is there a protective role for vaginal flora?
Jack D. Sobel
[J]. Current Infectious Disease Reports, 1999, 1 (4) : 379 - 383
[26] What's new in bacterial vaginosis and trichomoniasis?
Sobel, JD
[J]. INFECTIOUS DISEASE CLINICS OF NORTH AMERICA, 2005, 19 (02) : 387 - +
[27] Srinivasan Sujatha, 2008, Interdiscip Perspect Infect Dis, V2008, P750479, DOI 10.1155/2008/750479
[28] Verbeke G, 2009, SPRINGER SER STAT, P1
[29] Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy
Wang, Qiong
Garrity, George M.
Tiedje, James M.
Cole, James R.
[J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2007, 73 (16) : 5261 - 5267
[30] Bacterial flora of the female genital tract: function and immune regulation
Witkin, Steven S.
Linhares, Iara Moreno
Giraldo, Paulo
[J]. BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY, 2007, 21 (03) : 347 - 354

← 1 2 3 4 →