ABP1 and ROP6 GTPase Signaling Regulate Clathrin-Mediated Endocytosis in Arabidopsis Roots

被引:130
作者
Chen, Xu [1 ,2 ]
Naramoto, Satoshi [3 ,4 ]
Robert, Stephanie [1 ,2 ]
Tejos, Ricardo [1 ,2 ]
Loefke, Christian [5 ]
Lin, Deshu [6 ]
Yang, Zhenbiao [6 ]
Friml, Jiri [1 ,2 ,7 ,8 ]
机构
[1] Univ Ghent VIB, Dept Plant Syst Biol, B-9052 Ghent, Belgium
[2] Univ Ghent, Dept Plant Biotechnol & Genet, B-9052 Ghent, Belgium
[3] Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Bunkyo Ku, Tokyo 1130033, Japan
[4] RIKEN, Adv Sci Inst, Mol Membrane Biol Lab, Wako, Saitama 3510198, Japan
[5] Univ Gottingen, Dept Plant Biochem, Albrecht von Haller Inst Plant Sci, D-37077 Gottingen, Germany
[6] Univ Calif Riverside, Dept Bot & Plant Sci, Inst Integrat Genome Biol, Ctr Plant Cell Biol, Riverside, CA 92521 USA
[7] Masaryk Univ, Fac Sci, Dept Funct Genom & Prote, CZ-62500 Brno, Czech Republic
[8] Masaryk Univ, CEITEC, CZ-62500 Brno, Czech Republic
关键词
AUXIN-EFFLUX; PLANT-CELLS; PLASMA-MEMBRANE; TRANSPORT; POLARITY; EXPRESSION; DYNAMICS; CARRIER; PIN2;
D O I
10.1016/j.cub.2012.05.020
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The dynamic spatial and temporal distribution of the crucial plant signaling molecule auxin is achieved by feedback coordination of auxin signaling and intercellular auxin transport pathways [1, 2]. Developmental roles of auxin have been attributed predominantly to its effect on transcription; however, an alternative pathway involving AUXIN BINDING PROTEIN1 (ABP1) has been proposed to regulate clathrin-mediated endocytosis in roots and Rho-like GTPase (ROP)-dependent pavement cell interdigitation in leaves [3, 4]. In this study, we show that ROP6 and its downstream effector RIC1 regulate clathrin association with the plasma membrane for clathrin-mediated endocytosis, as well as for its feedback regulation by auxin. Genetic analysis revealed that ROP6/RIC1 acts downstream of ABP1 to regulate endocytosis. This signaling circuit is also involved in the feedback regulation of PIN-FORMED 1 (PIN1) and PIN2 auxin transporters activity (via its constitutive endocytosis) and corresponding auxin transport-mediated processes, including root gravitropism and leave vascular tissue patterning. Our findings suggest that the signaling module auxin ABP1 ROP6/RIC1 clathrin PIN1/PIN2 is a shared component of the feedback regulation of auxin transport during both root and aerial development.
引用
收藏
页码:1326 / 1332
页数:7
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