Nuclear DNA damage signalling to mitochondria in ageing (vol 17, pg 308, 2016)

被引：294

作者：

Fang, Evandro Fei

Scheibye-Knudsen, Morten

Chua, Katrin F.

Mattson, Mark P.

Croteau, Deborah L.

Bohr, Vilhelm A.

机构：

[1] Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, 21224, MD

[2] Department of Medicine, Division of Endocrinology, Gerontology, and Metabolism, School of Medicine, Stanford University, Stanford, 94305, CA

[3] Geriatric Research, Education, and Clinical Center, VA Palo Alto Health Care System, Palo Alto, 94304, CA

[4] Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, 21224, MD

[5] Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, 21205, MD

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2016年 / 17卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm.2016.14

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Mitochondrial dysfunction is a hallmark of ageing, and mitochondrial maintenance may lead to increased healthspan. Emerging evidence suggests a crucial role for signalling from the nucleus to mitochondria (NM signalling) in regulating mitochondrial function and ageing. An important initiator of NM signalling is nuclear DNA damage, which accumulates with age and may contribute to the development of age-associated diseases. DNA damage-dependent NM signalling constitutes a network that includes nuclear sirtuins and controls genomic stability and mitochondrial integrity. Pharmacological modulation of NM signalling is a promising novel approach for the prevention and treatment of age-associated diseases.

引用

页码：308 / 321

页数：1

共 1 条

[1]

Nuclear DNA damage signalling to mitochondria in ageing (vol 17, pg 308, 2016) [J].

Fang, Evandro Fei ;

Scheibye-Knudsen, Morten ;

Chua, Katrin F. ;

Mattson, Mark P. ;

Croteau, Deborah L. ;

Bohr, Vilhelm A. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2016, 17 (05) :308-321

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