Dendritic cells in cancer immunotherapy clinical trials: are we making progress?

被引：95

作者：

Butterfield, Lisa H. ^{[1
,2
,3
]}

机构：

[1] Univ Pittsburgh, Inst Canc, Dept Med, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Inst Canc, Dept Surg, Pittsburgh, PA 15213 USA

[3] Univ Pittsburgh, Inst Canc, Dept Immunol, Pittsburgh, PA 15213 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2013年 / 4卷

关键词：

cancer vaccines; tumor immunology; antigen presentation; dendritic cells; antigen loading;

D O I：

10.3389/fimmu.2013.00454

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DC) have been tested in cancer immunotherapy clinical trials for two decades. Over this time, the methods of DC culture (or manufacture) have evolved, the approaches for antigen loading have broadened, the maturation signals have varied and different sites of administration have been tested. The post-vaccination immunologic questions asked have also varied between trials and over time. In this review, I will consider multiple aspects of DC-based vaccines tested in cancer patients, including the cell culture, antigen loading, maturation, and delivery, as well as what we have learned from testing immune responses in vaccinated patients who have benefited clinically, and those who have not measurably benefited.

引用

页数：7

共 52 条

[1]

Banchereau J, 2001, CANCER RES, V61, P6451

[2] Prevention of colitis-associated colon cancer using a vaccine to target abnormal expression of the MUC1 tumor antigen [J].

Beatty, Pamela ;

Ranganathan, Sarangarajan ;

Finn, Olivera J. .

ONCOIMMUNOLOGY, 2012, 1 (03) :263-270

[3] T Cell Assays and MIATA: The Essential Minimum for Maximum Impact [J].

Britten, C. M. ;

Janetzki, S. ;

Butterfield, L. H. ;

Ferrari, G. ;

Gouttefangeas, C. ;

Huber, C. ;

Kalos, M. ;

Levitsky, H. I. ;

Maecker, H. T. ;

Melief, C. J. M. ;

O'Donnell-Tormey, J. ;

Odunsi, K. ;

Old, L. J. ;

Ottenhoff, T. H. M. ;

Ottensmeier, C. ;

Pawelec, G. ;

Roederer, M. ;

Roep, B. O. ;

Romero, P. ;

van der Burg, S. H. ;

Walter, S. ;

Hoos, A. ;

Davis, M. M. .

IMMUNITY, 2012, 37 (01) :1-2

[4]

Butterfield LH, 2003, CLIN CANCER RES, V9, P998

[5] Development of a potency assay for human dendritic cells: IL-12p70 production [J].

Butterfield, Lisa H. ;

Gooding, William ;

Whiteside, Theresa L. .

JOURNAL OF IMMUNOTHERAPY, 2008, 31 (01) :89-100

[6] Recommendations from the iSBTc-SITC/FDA/NCI Workshop on Immunotherapy Biomarkers [J].

Butterfield, Lisa H. ;

Palucka, A. Karolina ;

Britten, Cedrik M. ;

Dhodapkar, Madhav V. ;

Hakansson, Leif ;

Janetzki, Sylvia ;

Kawakami, Yutaka ;

Kleen, Thomas-Oliver ;

Lee, Peter P. ;

Maccalli, Cristina ;

Maecker, Holden T. ;

Maino, Vernon C. ;

Maio, Michele ;

Malyguine, Anatoli ;

Masucci, Giuseppe ;

Pawelec, Graham ;

Potter, Douglas M. ;

Rivoltini, Licia ;

Salazar, Lupe G. ;

Schendel, Dolores J. ;

Slingluff, Craig L., Jr. ;

Song, Wenru ;

Stroncek, David F. ;

Tahara, Hideaki ;

Thurin, Magdalena ;

Trinchieri, Giorgio ;

van Der Burg, Sjoerd H. ;

Whiteside, Theresa L. ;

Wigginton, Jon M. ;

Marincola, Francesco ;

Khleif, Samir ;

Fox, Bernard A. ;

Disis, Mary L. .

CLINICAL CANCER RESEARCH, 2011, 17 (10) :3064-3076

[7] Quality Controls in Cellular Immunotherapies: Rapid Assessment of Clinical Grade Dendritic Cells by Gene Expression Profiling [J].

Castiello, Luciano ;

Sabatino, Marianna ;

Zhao, Yingdong ;

Tumaini, Barbara ;

Ren, Jiaqiang ;

Ping, Jin ;

Wang, Ena ;

Wood, Lauren V. ;

Marincola, Francesco M. ;

Puri, Raj K. ;

Stroncek, David F. .

MOLECULAR THERAPY, 2013, 21 (02) :476-484

[8] Immune selective pressure and HLA class I antigen defects in malignant lesions [J].

Chang, Chien-Chung ;

Ferrone, Soldano .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2007, 56 (02) :227-236

[9] The Prioritization of Cancer Antigens: A National Cancer Institute Pilot Project for the Acceleration of Translational Research [J].

Cheever, Martin A. ;

Allison, James P. ;

Ferris, Andrea S. ;

Finn, Olivera J. ;

Hastings, Benjamin M. ;

Hecht, Toby T. ;

Mellman, Ira ;

Prindiville, Sheila A. ;

Viner, Jaye L. ;

Weiner, Louis M. ;

Matrisian, Lynn M. .

CLINICAL CANCER RESEARCH, 2009, 15 (17) :5323-5337

[10] A Dendritic Cell Vaccine Pulsed with Autologous Hypochlorous Acid-Oxidized Ovarian Cancer Lysate Primes Effective Broad Antitumor Immunity: From Bench to Bedside [J].

Chiang, Cheryl Lai-Lai ;

Kandalaft, Lana E. ;

Tanyi, Janos ;

Hagemann, Andrea R. ;

Motz, Gregory T. ;

Svoronos, Nikolaos ;

Montone, Kathleen ;

Mantia-Smaldone, Gina M. ;

Smith, Lori ;

Nisenbaum, Harvey L. ;

Levine, Bruce L. ;

Kalos, Michael ;

Czerniecki, Brian J. ;

Torigian, Drew A. ;

Powell, Daniel J., Jr. ;

Mick, Rosemarie ;

Coukos, George .

CLINICAL CANCER RESEARCH, 2013, 19 (17) :4801-4815

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