Dendritic cells in cancer immunotherapy clinical trials: are we making progress?

被引：95

作者：

Butterfield, Lisa H. ^{[1
,2
,3
]}

机构：

[1] Univ Pittsburgh, Inst Canc, Dept Med, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Inst Canc, Dept Surg, Pittsburgh, PA 15213 USA

[3] Univ Pittsburgh, Inst Canc, Dept Immunol, Pittsburgh, PA 15213 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2013年 / 4卷

关键词：

cancer vaccines; tumor immunology; antigen presentation; dendritic cells; antigen loading;

D O I：

10.3389/fimmu.2013.00454

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DC) have been tested in cancer immunotherapy clinical trials for two decades. Over this time, the methods of DC culture (or manufacture) have evolved, the approaches for antigen loading have broadened, the maturation signals have varied and different sites of administration have been tested. The post-vaccination immunologic questions asked have also varied between trials and over time. In this review, I will consider multiple aspects of DC-based vaccines tested in cancer patients, including the cell culture, antigen loading, maturation, and delivery, as well as what we have learned from testing immune responses in vaccinated patients who have benefited clinically, and those who have not measurably benefited.

引用

页数：7

共 52 条

[11] A Prescription for Human Immunology [J].

Davis, Mark M. .

IMMUNITY, 2008, 29 (06) :835-838

[12] Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy [J].

de Vries, IJM ;

Lesterhuis, WJ ;

Barentsz, JO ;

Verdijk, P ;

van Krieken, JH ;

Boerman, OC ;

Oyen, WJG ;

Bonenkamp, JJ ;

Boezeman, JB ;

Adema, GJ ;

Bulte, JWM ;

Scheenen, TWJ ;

Punt, CJA ;

Heerschap, A ;

Figdor, CG .

NATURE BIOTECHNOLOGY, 2005, 23 (11) :1407-1413

[13]

de Vries IJM, 2003, CANCER RES, V63, P12

[14] Review of clinical studies on dendritic cell-based vaccination of patients with malignant melanoma: assessment of correlation between clinical response and vaccine parameters [J].

Engell-Noerregaard, Lotte ;

Hansen, Troels Holz ;

Andersen, Mads Hald ;

Straten, Per Thor ;

Svane, Inge Marie .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2009, 58 (01) :1-14

[15] Regulatory Dendritic Cell Infusion Prolongs Kidney Allograft Survival in Nonhuman Primates [J].

Ezzelarab, M. B. ;

Zahorchak, A. F. ;

Lu, L. ;

Morelli, A. E. ;

Chalasani, G. ;

Demetris, A. J. ;

Lakkis, F. G. ;

Wijkstrom, M. ;

Murase, N. ;

Humar, A. ;

Shapiro, R. ;

Cooper, D. K. C. ;

Thomson, A. W. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2013, 13 (08) :1989-2005

[16] Molecular origins of cancer - Cancer immunology [J].

Finn, Olivera J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (25) :2704-2715

[17] Type I interferon response and innate immune sensing of cancer [J].

Fuertes, Mercedes B. ;

Woo, Seng-Ryong ;

Burnett, Byron ;

Fu, Yang-Xin ;

Gajewski, Thomas F. .

TRENDS IN IMMUNOLOGY, 2013, 34 (02) :67-73

[18] Trial watch Dendritic cell-based interventions for cancer therapy [J].

Galluzzi, Lorenzo ;

Senovilla, Laura ;

Vacchelli, Erika ;

Eggermont, Alexander ;

Fridman, Wolf Herve ;

Galon, Jerome ;

Sautes-Fridman, Catherine ;

Tartour, Eric ;

Zitvogel, Laurence ;

Kroemer, Guido .

ONCOIMMUNOLOGY, 2012, 1 (07) :1111-1134

[19] The secret ally: immunostimulation by anticancer drugs [J].

Galluzzi, Lorenzo ;

Senovilla, Laura ;

Zitvogel, Laurence ;

Kroemer, Guido .

NATURE REVIEWS DRUG DISCOVERY, 2012, 11 (03) :215-233

[20] Cancer classification using the Immunoscore: a worldwide task force [J].

Galon, Jerome ;

Pages, Franck ;

Marincola, Francesco M. ;

Angell, Helen K. ;

Thurin, Magdalena ;

Lugli, Alessandro ;

Zlobec, Inti ;

Berger, Anne ;

Bifulco, Carlo ;

Botti, Gerardo ;

Tatangelo, Fabiana ;

Britten, Cedrik M. ;

Kreiter, Sebastian ;

Chouchane, Lotfi ;

Delrio, Paolo ;

Arndt, Hartmann ;

Asslaber, Martin ;

Maio, Michele ;

Masucci, Giuseppe V. ;

Mihm, Martin ;

Vidal-Vanaclocha, Fernando ;

Allison, James P. ;

Gnjatic, Sacha ;

Hakansson, Leif ;

Huber, Christoph ;

Singh-Jasuja, Harpreet ;

Ottensmeier, Christian ;

Zwierzina, Heinz ;

Laghi, Luigi ;

Grizzi, Fabio ;

Ohashi, Pamela S. ;

Shaw, Patricia A. ;

Clarke, Blaise A. ;

Wouters, Bradly G. ;

Kawakami, Yutaka ;

Hazama, Shoichi ;

Okuno, Kiyotaka ;

Wang, Ena ;

O'Donnell-Tormey, Jill ;

Lagorce, Christine ;

Pawelec, Graham ;

Nishimura, Michael I. ;

Hawkins, Robert ;

Lapointe, Rejean ;

Lundqvist, Andreas ;

Khleif, Samir N. ;

Ogino, Shuji ;

Gibbs, Peter ;

Waring, Paul ;

Sato, Noriyuki .

JOURNAL OF TRANSLATIONAL MEDICINE, 2012, 10

← 1 2 3 4 5 6 →