Herb-drug interaction of Evodia rutaecarpa extract on the pharmacokinetics of theophylline in rats

被引：24

作者：

Jan, WC

Lin, LC

Chieh-Fu-Chen

Tsai, TH ^{[1
]}

机构：

[1] Natl Yang Ming Univ, Inst Pharmacol, Taipei, Taiwan

[2] Mackay Med Nursing & Management Coll, Taipei, Taiwan

[3] Natl Res Inst Chinese Med, Taipei 112, Taiwan

[4] Natl Yang Ming Univ, Inst Tradit Med, Taipei 112, Taiwan

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2005年 / 102卷 / 03期

关键词：

Evodia rutaecarpa; microdialysis; pharmacokinetics; theophylline; traditional Chinese medicine;

D O I：

10.1016/j.jep.2005.07.002

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The extract of Evodia rutaecarpa fruit and its preparation were used for the treatment of gastrointestinal disorders and headache. To assess the possible herb-drug interaction, the ethanol extract of Evodia ruraecarpa fruit (1 and 2 g/kg/day, p.o.) and the herbal preparation Wu-Chu-Yu-Tang (1 and 5 g/kg/day) were given to rats daily for three consecutive days and on the fourth day theophylline was administered (2 mg/kg, i.v.). Theophylline concentration in blood was measured by a microdialysis coupled to a liquid chromatographic system. Pharmacokinetic data were calculated by noncompartmental model. The results indicate that the theophylline level was significantly decreased by the pretreatment with the extract of Evodia rutaecarpa and herbal preparation Wu-Chu-Yu-Tang with dose-related manner. It is suggested that the herb-drug interaction may occur through the induction of the metabolism of theophylline. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：440 / 445

页数：6

共 22 条

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