Tofacitinib Citrate for the Treatment of Vitiligo A Pathogenesis-Directed Therapy

被引：224

作者：

Craiglow, Brittany G. ^{[1
]}

King, Brett A. ^{[1
]}

机构：

[1] Yale Univ, Dept Dermatol, Sch Med, New Haven, CT 06520 USA

来源：

JAMA DERMATOLOGY | 2015年 / 151卷 / 10期

关键词：

JANUS KINASE INHIBITOR; PLAQUE PSORIASIS; EFFICACY; SAFETY;

D O I：

10.1001/jamadermatol.2015.1520

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

IMPORTANCE Vitiligo is a common condition that is often emotionally devastating for patients. At present, no reliably effective treatments are available. OBSERVATIONS Recent advances in the understanding of the pathogenesis of vitiligo suggest that Janus kinase inhibitors may be a therapeutic option. We report a case of generalized vitiligo for which treatment with tofacitinib citrate, an oral Janus kinase 1/3 inhibitor, resulted in significant repigmentation. CONCLUSIONS AND RELEVANCE The results suggest that tofacitinib and other Janus kinase inhibitors may be effective in the treatment of vitiligo. Additional studies will be needed to confirm their efficacy and to explore their safety.

引用

页码：1110 / 1112

页数：3

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