Interplay between MgtC and PagC in Salmonella enterica serovar Typhimurium

被引：14

作者：

Alix, Eric ^{[2
]}

Miki, Tsuyoshi ^{[3
]}

Felix, Christine ^{[2
]}

Rang, Cecile ^{[2
]}

Figueroa-Bossi, Nara ^{[4
]}

Dernettre, Edith ^{[5
,6
]}

Blanc-Potard, Anne-Beatrice ^{[1
,2
]}

机构：

[1] INSERM, Espri 26, UFR Med, F-30908 Nimes 02, France

[2] Univ Montpellier I, UFR Med, F-30908 Nimes 02, France

[3] Kitasato Univ, Sch Pharmaceut Sci, Dept Microbiol, Minato Ku, Tokyo 1088641, Japan

[4] CNRS, Ctr Genet Mol, F-91198 Gif Sur Yvette, France

[5] INSERM, CNRS, UMR 5203, Inst Genom Fonct,U661, F-34094 Montpellier, France

[6] Univ Montpellier I, F-34094 Montpellier, France

来源：

MICROBIAL PATHOGENESIS | 2008年 / 45卷 / 03期

关键词：

Macrophage; MgtC; Nramp1; PagC; Salmonella typhimurium;

D O I：

10.1016/j.micpath.2008.06.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In Salmonella enterica serovar Typhimurium, MgtC and PagC are positively regulated by the PhoP-PhoQ two-component system, which is activated under magnesium deprivation. Both MgtC and PagC are of unknown function but have been involved in intramacrophage survival. We have found that the amount of PagC is lowered in a Delta mgtC mutant strain grown in magnesium depleted medium. However, the effect of MgtC on PagC does not account for the growth defect of a Delta mgtC mutant in macrophages since, in contrast to previous reports, our results indicate that PagC does not contribute to intramacrophage survival. In addition, a pagC null mutant is only poorly attenuated in Nramp1-negative or Nramp1-positive mice. On the other hand, a mgtC null mutant is significantly more attenuated with Nramp1-positive than Nramp1-negative mice, suggesting that a functional Nramp1 (Slc11a1) further limits the multiplication of this mutant within the host. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：236 / 240

页数：5

共 29 条

[1] MgtC: a key player in intramacrophage survival [J].