Effective controlled release of captopril by silylation of mesoporous MCM-41

被引：100

作者：

Qu, FY

Zhu, GS ^{[1
]}

Huang, SY

Li, SG

Qiu, SL

机构：

[1] Jilin Univ, State Key Lab Inorgan Synth & Preparat Chem, Changchun 130023, Peoples R China

[2] Jiamusi Univ, Chem & Pharmaceut Coll, Jiamusi 154007, Peoples R China

来源：

CHEMPHYSCHEM | 2006年 / 7卷 / 02期

关键词：

drug delivery; mesoporous materials; silicon; surface chemistry; X-ray diffraction;

D O I：

10.1002/cphc.200500294

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The release of the water-soluble drug Captopril is controlled by tailoring the surface properties of mesoporous silica via stepwise silylation. The degree of silylation is manipulated by adjusting the initial concentration of silylanizing reagent (trimethylchlorosilane, TMCS). The silylanized and drug-loaded samples are characterized by powder X-ray diffraction, Fourier transform IR spectroscopy, N-2 adsorption and desorption, Si-29 cross-polorization magic angle spinning NMR spectroscopy, and transmission electron microscopy. The drug-loading amount is correlated to the Brunauer-Emmett-Teller surface area and surface hydrophilicityl hydrophobicity of the mesoporous silica material, while drug release profiles con be controlled by tailoring the surface properties and pore size.

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页码：400 / 406

页数：7

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