The immunoregulatory role of IDO-producing human dendritic cells revisited

被引：80

作者：

Terness, P ^{[1
]}

Chuang, JJ ^{[1
]}

Opelz, G ^{[1
]}

机构：

[1] Heidelberg Univ, Inst Immunol, Dept Transplantat Immunol, D-69120 Heidelberg, Germany

来源：

TRENDS IN IMMUNOLOGY | 2006年 / 27卷 / 02期

关键词：

D O I：

10.1016/j.it.2005.12.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Following the finding that indoleamine 2,3-dioxygenase (IDO), an enzyme expressed in the placenta, prevents rejection of allogeneic fetuses in mice, many studies have focused on the role of IDO in the regulation of the immune response. Most arguments for an immunoregulatory role of IDO in vivo are based on observations in mice. Here, we critically examine the arguments for and against a function of IDO-expressing human dendritic cells (DCs) and conclude that proof for an immunoregulatory role in vivo is still lacking.

引用

页码：68 / 73

页数：6

共 37 条

[1] Indoleamine 2,3-dioxygenase expression in trans-planted NOD islets prolongs graft survival after adoptive transfer of diabetogenic splenocytes [J].

Alexander, AM ;

Crawford, M ;

Bertera, S ;

Rudert, WA ;

Takikawa, O ;

Robbins, PD ;

Trucco, M .

DIABETES, 2002, 51 (02) :356-365

[2]

Allegri G, 2003, ADV EXP MED BIOL, V527, P497

[3]

Allegri G, 2003, ADV EXP MED BIOL, V527, P455

[4] Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation [J].

Angelini, G ;

Gardella, S ;

Ardy, M ;

Ciriolo, MR ;

Filomeni, G ;

Di Trapani, G ;

Clarke, F ;

Sitia, R ;

Rubartelli, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (03) :1491-1496

[5] Studying the immunosuppressive role of indoleamine 2,3-dioxygenase:: tryptophan metabolites suppress rat allogeneic T-cell responses in vitro and in vivo [J].

Bauer, TM ;

Jiga, LP ;

Chuang, JJ ;

Randazzo, M ;

Opelz, G ;

Terness, P .

TRANSPLANT INTERNATIONAL, 2005, 18 (01) :95-100

[6]

Bodaghi B, 1999, J IMMUNOL, V162, P957

[7] Modulation of tryptophan catabolism by regulatory T cells [J].

Fallarino, F ;

Grohmann, U ;

Hwang, KW ;

Orabona, C ;

Vacca, C ;

Bianchi, R ;

Belladonna, ML ;

Fioretti, MC ;

Alegre, ML ;

Puccetti, P .

NATURE IMMUNOLOGY, 2003, 4 (12) :1206-1212

[8] T cell apoptosis by tryptophan catabolism [J].

Fallarino, I ;

Grohmann, U ;

Vacca, C ;

Bianchi, R ;

Orabona, C ;

Spreca, A ;

Fioretti, MC ;

Puccetti, P .

CELL DEATH AND DIFFERENTIATION, 2002, 9 (10) :1069-1077

[9] Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase [J].

Frumento, G ;

Rotondo, R ;

Tonetti, M ;

Damonte, G ;

Benatti, U ;

Ferrara, GB .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (04) :459-468

[10] CTLA-4-Ig regulates tryptophan catabolism in vivo [J].

Grohmann, U ;

Orabona, C ;

Fallarino, F ;

Vacca, C ;

Calcinaro, F ;

Falorni, A ;

Candeloro, P ;

Belladonna, ML ;

Bianchi, R ;

Fioretti, MC ;

Puccetti, P .

NATURE IMMUNOLOGY, 2002, 3 (11) :1097-1101

← 1 2 3 4 →