Morphological observation of canine natural killer cells mediated cytotoxicity

被引：3

作者：

Nariai, Y

Nariai, K

Kosaka, T

Kuwabara, M

Kiuchi, Y

机构：

[1] Yokohama City Univ, Sch Med, Lab Anim Facil, Kanazawa Ku, Kanagawa 2360004, Japan

[2] Jikei Univ, Sch Med, Res Ctr Med Sci, Lab Anim Facilities,Minato Ku, Tokyo 1050003, Japan

[3] Nihon Univ, Coll Bioresource Sci, Kanagawa 2520813, Japan

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 1999年 / 61卷 / 07期

关键词：

canine; NK; SEM;

D O I：

10.1292/jvms.61.835

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The cytotoxic effects of canine NK cells on CL-I target cells were examined by scanning electron microscopy (SEM). NK cell mediated cytotoxicity on CL-I target cells was detected by Cr-51 release assay. SEM showed that a canine NK cell extended projections to the CL-I target cell. Furthermore, the surface of CL-1 target cells changed a mesh-like structure. Therefore, the cytotoxic effects of canine NK cells on CL-1 target cells were morphologically demonstrated.

引用

页码：835 / 838

页数：4

共 35 条

[1]

BUTTNER M, 1993, NAT IMMUN, V12, P92

[2]

CARPEN O, 1982, J IMMUNOL, V128, P2691

[3]

DUKE RC, 1986, J IMMUNOL, V137, P1442

[4]

FARRAM E, 1983, J IMMUNOL, V130, P1252