Modifying the surface properties of superparamagnetic iron oxide nanoparticles through a sol-gel approach

被引:943
作者
Lu, Y [1 ]
Yin, YD [1 ]
Mayers, BT [1 ]
Xia, YN [1 ]
机构
[1] Univ Washington, Dept Mat Sci & Engn, Dept Chem, Seattle, WA 98195 USA
关键词
D O I
10.1021/nl015681q
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
This paper describes a sol-gel approach for the coating of superparamagnetic iron oxide nanoparticles with uniform shells of amorphous silica. The coating process has been successfully applied to particles contained in a commercial ferrofluid (e.g., the EMG 304 of Ferrofluidics) and those synthesized through a wet chemical process. The thickness of silica coating could be conveniently controlled in the range of 2-100 nm by changing the concentration of the sol-gel solution. Fluorescent dyes, for example, 7-(dimethylamino)-4-methylcoumarin-3-isothiocyanate (DACITC) and tetramethylrhodamine-5-isothiocyanate (5-TRITC), have also been incorporated into the silica shells by covalently coupling these organic compounds with the sol-gel precursor, These multifunctional nanoparticles are potentially useful in a number of areas because they can be simultaneously manipulated with an externally applied magnetic field and characterized in situ using conventional fluorescence microscopy.
引用
收藏
页码:183 / 186
页数:4
相关论文
共 40 条
  • [1] Synthesis of iron oxide nanoparticles used as MRI contrast agents: A parametric study
    Babes, L
    Denizot, B
    Tanguy, G
    Le Jeune, JJ
    Jallet, P
    [J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 1999, 212 (02) : 474 - 482
  • [2] BRUCE CA, 1982, Patent No. 4333961
  • [3] Preparation of ultrafine silica- and PEG-coated magnetite particles
    Butterworth, MD
    Illum, L
    Davis, SS
    [J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2001, 179 (01) : 93 - 102
  • [4] CREATION OF TEMPLATED COMPLEX TOPOLOGICAL MORPHOLOGIES IN COLLOIDAL SILICA
    CHANG, SY
    LIU, L
    ASHER, SA
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (15) : 6745 - 6747
  • [5] Ultrasensitive magnetic biosensor for homogeneous immunoassay
    Chemla, YR
    Crossman, HL
    Poon, Y
    McDermott, R
    Stevens, R
    Alper, MD
    Clarke, J
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (26) : 14268 - 14272
  • [6] Cornell R. M., 1996, IRON OXIDES STRUCTUR, P493
  • [7] Control of packing order of self-assembled monolayers of magnetite nanoparticles with and without SiO2 coating by microwave irradiation
    Correa-Duarte, MA
    Giersig, M
    Kotov, NA
    Liz-Marzan, LM
    [J]. LANGMUIR, 1998, 14 (22) : 6430 - 6435
  • [8] Concentration-dependent sedimentation of dilute magnetic fluids and magnetic silica dispersions
    Donselaar, LN
    Philipse, AP
    Suurmond, J
    [J]. LANGMUIR, 1997, 13 (23) : 6018 - 6025
  • [9] EFFECTS OF BETA-ADRENERGIC-RECEPTOR ACTIVATION ON ALVEOLAR MACROPHAGE CYTOPLASMIC MOTILITY
    FUKUSHIMA, T
    SEKIZAWA, K
    JIN, Y
    YAMAYA, M
    SASAKI, H
    TAKISHIMA, T
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 265 (01): : L67 - L72
  • [10] MAGNETICALLY CONTROLLED TARGETED MICRO-CARRIER SYSTEMS
    GUPTA, PK
    HUNG, CT
    [J]. LIFE SCIENCES, 1989, 44 (03) : 175 - 186