Preparation of ultrafine silica- and PEG-coated magnetite particles

被引：164

作者：

Butterworth, MD ^{[1
]}

Illum, L ^{[1
]}

Davis, SS ^{[1
]}

机构：

[1] Univ Nottingham, Inst Pharmaceut Sci, Nottingham NG7 2RD, England

来源：

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 2001年 / 179卷 / 01期

关键词：

magnetite particles; PEG coating; trimethoxysilane-PEG; diagnostic imaging;

D O I：

10.1016/S0927-7757(00)00633-6

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The effect of the molecular weight, reaction temperature and polymer concentration were investigated. The PEG coverage could be controlled by the selection of the polymer; the molecular coverage increased with decrease in polymer molecular weight. A method for synthesising PEG-coated magnetite particles for use in diagnostic imaging is described. Magnetite particles in aqueous conditions were reacted with Si(OR)(2)R'R" (trimethosysilane-PEG, R = Me; R' = Ome; R" = PEG). These PEG-coated magnetite particles showed greatly enhanced colloid stability properties with respect to the uncoated particles. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：93 / 102

页数：10

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