First crystallographic signature of the highly ordered supramolecular helical assemblage from a tripeptide containing a non-coded amino acid

被引：34

作者：

Haldar, D

Majia, SK

Sheldrick, WS

Banerjee, A ^{[1
]}

机构：

[1] Indian Assoc Cultivat Sci, Dept Biol Chem, Kolkata 700032, W Bengal, India

[2] Ruhr Univ Bochum, Lehrstuhl Analyt Chem, D-44780 Bochum, Germany

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 14期

关键词：

supramolecular helix; Aib; amyloid fibrils;

D O I：

10.1016/S0040-4039(02)00283-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The model tripeptide Boc-Leu(1)-Aib(2)-Phe(3)-OMe 1 containing a non-coded amino acid residue (Aib: alpha-amino isobutyric acid) forms a supramolecular helical assemblage via non-covalent interactions in single crystals. The SEM image of the peptide 1 in the solid state shows the ribbon like fibrillar morphology, a characteristic feature of highly ordered aggregated fibrils like amyloid fibrils. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：2653 / 2656

页数：4

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