Pulcherrimins A-D, novel diterpene dibenzoates from Caesalpinia pulcherrima with selective activity against DNA repair-deficient yeast mutants

被引：38

作者：

Patil, AD

Freyer, AJ

Webb, RL

Zuber, G

Reichwein, R

Bean, MF

Faucette, L

Johnson, RK

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,DEPT ANALYT SCI,R&D,KING OF PRUSSIA,PA 19406

[2] SMITHKLINE BEECHAM PHARMACEUT,DEPT PHYS & STRUCT CHEM,R&D,KING OF PRUSSIA,PA 19406

来源：

TETRAHEDRON | 1997年 / 53卷 / 05期

关键词：

D O I：

10.1016/S0040-4020(96)01135-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bioassay-guided fractionation of the MeOH/CH2Cl2 extract of the roots of Caesalpinia pulcherrima yielded four novel dibenzoate diterpenes, pulcherrimins A, B, C and D (1-4). The structures of these compounds including their absolute configuration were established by interpretation of spectral data and CD measurements. Pulcherrimins A and B (1 and 2) were found to be active in DNA repair-deficient yeast mutant. (C) 1997, Elsevier Science Ltd.

引用

页码：1583 / 1592

页数：10

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