MECHANISM-BASED ISOLATION AND STRUCTURE OF SOME ANTICANCER ACTIVE NATURAL-PRODUCTS

被引：43

作者：

GUNATILAKA, AAL ^{[1
]}

KINGSTON, DGI ^{[1
]}

JOHNSON, RK ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,KING OF PRUSSIA,PA 19406

来源：

PURE AND APPLIED CHEMISTRY | 1994年 / 66卷 / 10-11期

关键词：

D O I：

10.1351/pac199466102219

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Application of a mechanism-based anticancer bioassay employing DNA repair-or recombination-deficient mutants of the yeast Saccharomyces cerevisiae for screening and subsequent bioassay-guided fractionation of bioactive higher plant and bryophyte extracts led to the isolation of a variety of natural products with potential anticancer activity. Presented herein are interesting structural features of some representative examples of natural products active in our mechanism-based bioassay and cytotoxicity assays along with structure-activity relationships of synthetic analogs of some of them.

引用

页码：2219 / 2222

页数：4

共 7 条

[1] 2 BIOACTIVE PTEROCARPANS FROM ERYTHRINA-BURANA [J].

DAGNE, E ;

GUNATILAKA, AAL ;

KINGSTON, DGI ;

ALEMU, M ;

HOFMANN, G ;

JOHNSON, RK .

JOURNAL OF NATURAL PRODUCTS, 1993, 56 (10) :1831-1834

[2]

ENG WK, 1988, MOL PHARMACOL, V34, P775

[3]

Game J., 1983, YEAST GENETICS FUNDA, P109

[4] BIOACTIVE ERGOST-5-ENE-3-BETA,7-ALPHA-DIOL DERIVATIVES FROM PSEUDOBERSAMA-MOSSAMBICENSIS [J].

GUNATILAKA, AAL ;

SAMARANAYAKE, G ;

KINGSTON, DGI ;

HOFFMANN, G ;

JOHNSON, RK .

JOURNAL OF NATURAL PRODUCTS, 1992, 55 (11) :1648-1654

[5] BIOACTIVE FURANONAPHTHOQUINONES FROM CRESCENTIA-CUJETE [J].

HELTZEL, CE ;

GUNATILAKA, AAL ;

GLASS, TE ;

KINGSTON, DGI ;

HOFFMANN, G ;

JOHNSON, RK .

JOURNAL OF NATURAL PRODUCTS, 1993, 56 (09) :1500-1505

[6] FUROFURANONAPHTHOQUINONES - BIOACTIVE COMPOUNDS WITH A NOVEL FUSED-RING SYSTEM FROM CRESCENTIA-CUJETE [J].

HELTZEL, CE ;

GUNATILAKA, AAL ;

GLASS, TE ;

KINGSTON, DGI .

TETRAHEDRON, 1993, 49 (31) :6757-6762

[7]

Johnson R. K., 1986, IN VITRO IN VIVO MOD, P15

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