Lipid bilayer fragments and disks in drug delivery

被引：39

作者：

Carmona-Ribeiro, AM ^{[1
]}

机构：

[1] Univ Sao Paulo, Dept Bioquim, Inst Quim, BR-05513970 Sao Paulo, Brazil

来源：

CURRENT MEDICINAL CHEMISTRY | 2006年 / 13卷 / 12期

关键词：

antimicrobial activity; disks; bilayer fragments; synergism; fungicides; lipid capsules for drugs;

D O I：

10.2174/092986706776872925

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Certain lipids can be dispersed as colloidally stable bilayer fragments (BP) or disks with interesting properties for solubilization and delivery of hydrophobic or amphiphilic drugs. They were first observed and characterized as such in the nineties but remained silent in the literature regarding applications for drug delivery. Only recently their potential for delivery of hydrophobic drugs started to be realized. This review deals with electrostatically or sterically stabilized bilayer fragments which provided excellent solubilization sites for antifungal drugs, acted as drugs themselves against bacteria or fungus, could be loaded with amphiphilic drugs or produced lipid-covered drug particles to be delivered as a synergistic formulation in vivo.

引用

页码：1359 / 1370

页数：12

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