One-pot synthesis of dihydropyrimidones using silica-supported heteropoly acid as an efficient and reusable catalyst: Improved protocol conditions for the Biginelli reaction

被引：96

作者：

Rafiee, E ^{[1
]}

Shahbazi, F ^{[1
]}

机构：

[1] Razi Univ, Fac Sci, Dept Chem, Kermanshah 67149, Iran

来源：

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL | 2006年 / 250卷 / 1-2期

关键词：

heterogeneous catalysts; dihydropyrimidinones or thiones (DHPMs); supported heteropoly acid; Biginelli reaction; multi component reactions (MCR);

D O I：

10.1016/j.molcata.2006.01.049

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

An efficient synthesis of 3,4-dihydropyrimidinones or thiones (DHPMs) is described, using silica-supported heteropoly acid H3PW12O40/SiO2 (PW/SiO2) for the first time as the catalyst from an aldehyde, beta-keto ester and urea or thiourea in acetonitrile. Compared to the classical Biginelli reaction conditions, this method consistently has the advantage of excellent yields, mild reaction conditions, ease of workup, survival of different functional groups, and short reaction times. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：57 / 61

页数：5

共 58 条

[1] DIHYDROPYRIMIDINE CALCIUM-CHANNEL BLOCKERS .3. 3-CARBAMOYL-4-ARYL-1,2,3,4-TETRAHYDRO-6-METHYL-5-PYRIMIDINECARBOXYLIC ACID-ESTERS AS ORALLY EFFECTIVE ANTIHYPERTENSIVE AGENTS [J].