New protocol for Biginelli reaction-a practical synthesis of Monastrol

被引：75

作者：

Bose, DS ^{[1
]}

Sudharshan, M ^{[1
]}

Chavhan, SW ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Fine Chem Lab, Div Organ Chem 3, Hyderabad 500007, Andhra Pradesh, India

来源：

ARKIVOC | 2005年

关键词：

mitotic; monastrol; Biginelli reaction; benzyltriethylammonium chloride; multicomponent reaction; dihydropyrimidin-2(1H)-ones;

D O I：

10.3998/ark.5550190.0006.325

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, efficient, and cost-effective method has been developed for the synthesis of 3,4-dihydropyrimidin- 2(1H)-ones by a one-pot three component cyclocondensation reaction of 1,3 dicarbonyl compound, aldehyde, and urea using benzyltriethylammonium chloride as the catalyst, under solvent-free conditions: the scope of this protocol is utilized for the synthesis of mitotic Kinesin EG5 inhibitor monastrol.

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收藏

页码：228 / 236

页数：9

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