An advantage of low-molecular-weight heparin (LMWH) is its lower risk of heparin-induced thrombocytopenia (HIT) compared with unfractionated heparin (UFH). In this issue of Blood, Prandoni and colleagues question whether heparin-induced thrombocytopenia (HIT) is reduced by low-molecular-weight heparin (LMWH) in medical patients.