Practical synthesis of the rebeccamycin aglycone and related analogs by oxidative cyclization of bisindolylmaleimides with a Wacker-type catalytic system

被引：32

作者：

Wang, JJ ^{[1
]}

Rosingana, M ^{[1
]}

Watson, DJ ^{[1
]}

Dowdy, ED ^{[1
]}

Discordia, RP ^{[1
]}

Soundarajan, N ^{[1
]}

Li, WS ^{[1
]}

机构：

[1] Bristol Myers Squibb Co, Pharmaceut Res Inst, New Brunswick, NJ 08903 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 51期

关键词：

D O I：

10.1016/S0040-4039(01)02021-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Using atmospheric O-2 as the stoichiometric oxidant, Pd2+/Cu2+-catalyzed oxidative cyclization of the corresponding bisindolylmaleimides provides the rebeccamycin aglycone and related indolo[2,3-a]pyrrolo[3,4-c]carbazoles in 58-88% yield. The method is operationally simple and utilizes readily prepared substrates, making the process amenable to scaleup. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：8935 / 8937

页数：3

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