Design and DNA-binding of metallo-supramolecular cylinders conjugated to peptides

被引：15

作者：

Cardo, Lucia ^{[1
]}

Hannon, Michael J. ^{[1
]}

机构：

[1] Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England

来源：

INORGANICA CHIMICA ACTA | 2009年 / 362卷 / 03期

关键词：

Bioinorganic chemistry; Metallo-supramolecular chemistry; Supramolecular cylinders; Peptide functionalisation; DNA-binding; Artificial nuclease; DNA coiling; NUCLEIC-ACID RECOGNITION; SOLID-PHASE SYNTHESIS; MINOR-GROOVE; PLATINUM COMPLEX; ANTITUMOR; CLEAVAGE; INTERCALATORS; DICHROISM; CHEMISTRY; COILING;

D O I：

10.1016/j.ica.2008.02.050

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Di-nuclear metallo-supramolecular "cylinders", based on bis-pyridylimine ligands, are end-functionalised with short peptides. The design and synthesis of one tetra-cationic triple-stranded (iron(II)) and three di-cationic double-stranded (copper(I) or silver(I)) cylinder-peptide conjugates are described. DNA-binding experiments, using circular and linear dichroism spectroscopies, confirm the binding and indicate that the iron(II) complexes cause DNA to bend or coil. Artificial nuclease activity by the copper(I) complexes is demonstrated by gel electrophoresis studies. (C) 2008 Elsevier B. V. All rights reserved.

引用

页码：784 / 792

页数：9

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