More TORC for the gluconeogenic engine

被引：14

作者：

Cheng, A

Saltiel, AR

机构：

[1] Univ Michigan, Med Ctr, Inst Life Sci, Dept Internal Med, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Med Ctr, Inst Life Sci, Dept Physiol, Ann Arbor, MI 48109 USA

来源：

BIOESSAYS | 2006年 / 28卷 / 03期

关键词：

D O I：

10.1002/bies.20375

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatic gluconeogenesis plays a key role in the maintenance of glucose homeostasis. The hormone glucagon stimulates this process, whereas insulin and adiponectin are inhibitory. In a recent report, Koo et al identify the transcriptional regulator TORC2 (Transducer of Regulated CREB activity 2) as a pivotal component of the gluconeogenic program.((1)) Both insulin and AMPK increase the phosphorylation of TORC2, while glucagon suppresses it. This in turn regulates the nuclear/cytoplasmic shuttling of TORC2 and its ability to transactivate gluconeogenic genes. Thus, TORC2 might serve as a gluconeogenic "molecular switch" that senses hormones and cellular energy status.

引用

页码：231 / 234

页数：4

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