Complete genomic structure of the CLCN6 and CLCN7 putative chloride channel genes

被引：16

作者：

Kornak, U

Bösl, MR

Kubisch, C

机构：

[1] Univ Hamburg, Zentrum Mol Neurobiol, D-20246 Hamburg, Germany

[2] Univ Bonn, Inst Humangenet, D-53111 Bonn, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1999年 / 1447卷 / 01期

关键词：

chloride channel; CLC family; CLCN6; CLCN7; gene structure;

D O I：

10.1016/S0167-4781(99)00128-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The CLC family of voltage-gated chloride channels comprises nine members in mammals. CLCN6 and CLCN7 belong to a novel, poorly characterized subbranch of this family. We investigated the genomic organization of the human CLCN6 gene, as well as the murine CLCN6 and CLCN7 genes. The human and murine CLCN6 genes both consist of 23 exons and share a nearly identical genomic structure. The coding region of mouse CLCN7 is composed of 25 exons. Comparison of the genomic organization of CLCN6 and CLCN7 genes shows that just eight introns are located at corresponding cDNA positions. Moreover, no significant gene structure homology to other members of the CLC family could be detected indicating a great structural diversity of mammalian CLC genes. (C) 1999 Elsevier Science B.V. All rights reserved.

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页码：100 / 106

页数：7

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