Processes in atherogenesis: Complement activation

被引:81
作者
Torzewski, J
Bowyer, DE
Waltenberger, J
Fitzsimmons, C
机构
[1] UNIV CAMBRIDGE,DEPT PATHOL,CAMBRIDGE CB2 1QP,ENGLAND
[2] UNIV ULM,MED CTR,DEPT INTERNAL MED 2,D-89081 ULM,GERMANY
关键词
complement activation; membrane attack complex; C5b-9; atherosclerosis;
D O I
10.1016/S0021-9150(97)00100-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The complement system consists of a complex group of plasma proteins, which, on activation, lead to a cascade of interactions culminating in the production of a variety of pro-inflammatory molecules. The system also contains cellular receptors for complement fragments produced during activation and regulatory molecules. It is part of the innate immune system representing humoral defence, but in certain circumstances may itself contribute to disease. In the formation of atherosclerotic lesions, there are two outstanding cellular phenomena, monocyte recruitment, with subsequent development of lipid-filled foam cells and smooth muscle cell activation. Subendothelial deposition of low density lipoprotein appears to be an important stimulus in these events and substantial evidence suggests that complement activation may be a link between lipoprotein deposition and subsequent lesion development. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码:131 / 138
页数:8
相关论文
共 77 条
[1]   TERMINAL COMPLEMENT PROTEINS C5B-9 RELEASE BASIC FIBROBLAST GROWTH-FACTOR AND PLATELET-DERIVED GROWTH-FACTOR FROM ENDOTHELIAL-CELLS [J].
BENZAQUEN, LR ;
NICHOLSONWELLER, A ;
HALPERIN, JA .
JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (03) :985-992
[2]  
BHAKDI S, 1995, J EXP MED, V182, P1959, DOI 10.1084/jem.182.6.1959
[3]   FUNCTIONS AND RELEVANCE OF THE TERMINAL COMPLEMENT SEQUENCE [J].
BHAKDI, S ;
HUGO, F ;
TRANUMJENSEN, J .
BLUT, 1990, 60 (06) :309-318
[4]  
BHAKDI S, 1992, ARTERIOSCLER THROMB, V12, P536
[5]   Autoantibody titers to oxidized low-density lipoprotein in patients with coronary atherosclerosis [J].
Bui, MN ;
Sack, MN ;
Moutsatsos, G ;
Lu, DY ;
Katz, P ;
McCown, R ;
Breall, JA ;
Rackley, CE .
AMERICAN HEART JOURNAL, 1996, 131 (04) :663-667
[6]  
CERILLI J, 1987, TRANSPLANT P, V19, P47
[7]  
CHAO FF, 1988, AM J PATHOL, V131, P73
[8]  
CYBULSKI A, 1993, AM J PHYSIOL, V265, P551
[9]   LP(A) LIPOPROTEIN, IGG, IGA AND IGM ANTIBODIES TO CHLAMYDIA-PNEUMONIAE AND HLA CLASS-II GENOTYPE IN EARLY CORONARY-ARTERY DISEASE [J].
DAHLEN, GH ;
BOMAN, J ;
BIRGANDER, LS ;
LINDBLOM, B .
ATHEROSCLEROSIS, 1995, 114 (02) :165-174
[10]   HYPOTHESIS - AN IMMUNOLOGICAL VIEW OF ATHEROGENESIS [J].
DAVIES, DF .
JOURNAL OF ATHEROSCLEROSIS RESEARCH, 1969, 10 (02) :253-&