Processes in atherogenesis: Complement activation

被引:81
作者
Torzewski, J
Bowyer, DE
Waltenberger, J
Fitzsimmons, C
机构
[1] UNIV CAMBRIDGE,DEPT PATHOL,CAMBRIDGE CB2 1QP,ENGLAND
[2] UNIV ULM,MED CTR,DEPT INTERNAL MED 2,D-89081 ULM,GERMANY
关键词
complement activation; membrane attack complex; C5b-9; atherosclerosis;
D O I
10.1016/S0021-9150(97)00100-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The complement system consists of a complex group of plasma proteins, which, on activation, lead to a cascade of interactions culminating in the production of a variety of pro-inflammatory molecules. The system also contains cellular receptors for complement fragments produced during activation and regulatory molecules. It is part of the innate immune system representing humoral defence, but in certain circumstances may itself contribute to disease. In the formation of atherosclerotic lesions, there are two outstanding cellular phenomena, monocyte recruitment, with subsequent development of lipid-filled foam cells and smooth muscle cell activation. Subendothelial deposition of low density lipoprotein appears to be an important stimulus in these events and substantial evidence suggests that complement activation may be a link between lipoprotein deposition and subsequent lesion development. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码:131 / 138
页数:8
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