Valproic acid-mediated Hsp70 induction and anti-apoptotic neuroprotection in SH-SY5Y cells

被引：69

作者：

Pan, TH

Li, XQ

Xie, WJ

Jankovic, J

Le, W ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Neurol, Parkinson Dis Res Lab, Houston, TX 77030 USA

[2] Univ Texas, MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Neurol, Parkinsons Dis Ctr, Houston, TX 77030 USA

[4] Baylor Coll Med, Dept Neurol, Movement Disorder Clin, Houston, TX 77030 USA

来源：

FEBS LETTERS | 2005年 / 579卷 / 30期

关键词：

valproic acid; neuroprotection; heat shock protein; Hsp70; p-Akt; p-B cell lymphoma protein-2; phospho-p44/42 mitogen-activated protein kinase;

D O I：

10.1016/j.febslet.2005.10.067

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Valproic acid (VPA), an anticonvulsant and mood-stabilizing drug, has been reported to exert neuroprotection against a variety of insults. We now show that VPA attenuates rotenone (a potent complex I inhibitor)-induced apoptosis through the induction of heat shock protein 70, which may interact with apoptotic-protease-activating factor 1. Activation of p-Akt, p-Bcl-2, as well as p-Erk1/2 by VPA may be co-contributors to the protection. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

收藏

页码：6716 / 6720

页数：5

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