Biomarkers in the diagnosis of ischemic stroke - A systematic review

被引：133

作者：

Whiteley, William ^{[1
]}

Tseng, Mei-Chiun ^{[2
]}

Sandercock, Peter ^{[1
]}

机构：

[1] Univ Edinburgh, Div Clin Neurosci, Edinburgh EH8 9YL, Midlothian, Scotland

[2] Natl Sun Yat Sen Univ, Kaohsiung, Taiwan

来源：

STROKE | 2008年 / 39卷 / 10期

关键词：

biomarker; stroke; hemorrhagic stroke; ischemic stroke; diagnosis;

D O I：

10.1161/STROKEAHA.107.511261

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose - The diagnosis of ischemic stroke can be difficult. CT may be normal in the early stages of ischemic stroke or in patients with minor symptoms and MR is not always possible. Many blood markers have been proposed for the diagnosis of stroke in the acute setting. Methods and Results - We have systematically reviewed the diagnostic literature and found 21 studies testing 58 single biomarkers and 7 panels of several biomarkers. Although all show either a high sensitivity or specificity, there are limitations in the design and reporting of all the studies that mean no biomarker can be recommended for use in clinical practice. Conclusions - We make recommendations for the design and reporting of studies of diagnostic blood biomarkers in stroke.

引用

页码：2902 / 2909

页数：8

共 38 条

[1] Ischemia-modified albumin in acute stroke [J].

Abboud, Halim ;

Labreuche, Julien ;

Meseguer, Elena ;

Lavallee, Philippa C. ;

Simon, Olivier ;

Olivot, Jean-Marc ;

Mazighi, Mikael ;

Dehoux, Monique ;

Benessiano, Joelle ;

Steg, Philippe Gabriel ;

Amarenco, Pierre .

CEREBROVASCULAR DISEASES, 2007, 23 (2-3) :216-220

[2] Approximate is better than "exact" for interval estimation of binomial proportions [J].

Agresti, A ;

Coull, BA .

AMERICAN STATISTICIAN, 1998, 52 (02) :119-126

[3] PARK7 and nucleoside diphosphate kinase A as plasma markers for the early diagnosis of stroke [J].

Allard, L ;

Burkhard, PR ;

Lescuyer, P ;

Burgess, JA ;

Walter, N ;

Hochstrasser, DF ;

Sanchez, JC .

CLINICAL CHEMISTRY, 2005, 51 (11) :2043-2051

[4] ApoC-I and ApoC-III as potential plasmatic markers to distinguish between ischemic and hemorrhagic stroke [J].

Allard, L ;

Lescuyer, P ;

Burgess, J ;

Leung, KY ;

Ward, M ;

Walter, N ;

Burkhard, PR ;

Corthals, G ;

Hochstrasser, DF ;

Sanchez, JC .

PROTEOMICS, 2004, 4 (08) :2242-2251

[5]

ALLARD L, 2005, CEREBROVASC DIS, V19, P47

[6]

Allard L, 2007, BIOMARK INSIGHTS, V2, P155

[7] Candidate-based proteomics in the search for biomarkers of cardiovascular disease [J].

Anderson, L .

JOURNAL OF PHYSIOLOGY-LONDON, 2005, 563 (01) :23-60

[8] Systematic reviews of diagnostic accuracy studies require study by study examination: first for heterogeneity, and then for sources of heterogeneity [J].

Begg, CB .

JOURNAL OF CLINICAL EPIDEMIOLOGY, 2005, 58 (09) :865-866

[9] The STARD statement for reporting studies of diagnostic accuracy: Explanation and elaboration [J].

Bossuyt, PM ;

Reitsma, JB ;

Bruns, DE ;

Gatsonis, CA ;

Glasziou, PP ;

Irwig, LM ;

Moher, D ;

Rennie, D ;

de Vet, HCW ;

Lijmer, JG .

CLINICAL CHEMISTRY, 2003, 49 (01) :7-18

[10] Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison [J].

Chalela, Julio A. ;

Kidwell, Chelsea S. ;

Nentwich, Lauren M. ;

Luby, Marie ;

Butman, John A. ;

Demchuk, Andrew M. ;

Hill, Michael D. ;

Patronas, Nicholas ;

Latour, Lawrence ;

Warach, Steven .

LANCET, 2007, 369 (9558) :293-298

← 1 2 3 4 →