Chronic active Epstein-Barr virus infection (CAEBV) successfully treated with allogeneic peripheral blood stem cell transplantation

被引：23

作者：

Taketani, T

Kikuchi, A

Inatomi, J

Hanada, R

Kawaguchi, H

Ida, K

Oh-ishi, T

Arai, T

Kishimoto, H

Yamamoto, K

机构：

[1] Saitama Childrens Med Ctr, Div Hematol Oncol, Saitama 3398551, Japan

[2] Saitama Childrens Med Ctr, Div Infect Dis Immunol & Allergy, Saitama 3398551, Japan

[3] Saitama Childrens Med Ctr, Dept Radiol, Saitama 3398551, Japan

[4] Saitama Childrens Med Ctr, Dept Pathol, Saitama 3398551, Japan

来源：

BONE MARROW TRANSPLANTATION | 2002年 / 29卷 / 06期

关键词：

CAEBV; malignant lymphoma; allo PBSCT; EBV in situ hybridization;

D O I：

10.1038/sj.bmt.1703392

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

We report a pediatric case of CAEBV and T cell-based Hodgkin's-like disease successfully treated with allo PBSCT from an HLA-matched sibling. The diagnosis of CAEBV was made from clinical signs and the presence of the EBV genome in PBMC and tumor cells. Conditioning with busulfan (BU) + etoposide (VP16) + cyclophosphamide (CY) was effective and well tolerated. EBV was totally eradicated by 3 months after allo PBSCT. Although she suffered from chronic GVHD of the liver, she has been well and free of disease for 47 months since PBSCT. We suggest allo PBSCT for CAEBV as a potent therapeutic strategy for eradication of the EBV genome and allowing immunological reconstitution.

引用

收藏

页码：531 / 533

页数：3

相关论文

共 11 条

[1] Allogeneic peripheral blood stem cell transplantation for the treatment of chronic active Epstein-Barr virus infection [J].

Fujii, N ;

Takenaka, K ;

Hiraki, A ;

Maeda, Y ;

Ikeda, K ;

Shinagawa, K ;

Ashiba, A ;

Munemasa, M ;

Sunami, K ;

Hiramatsu, Y ;

Ishimaru, F ;

Niiya, K ;

Yoshino, T ;

Harada, M .

BONE MARROW TRANSPLANTATION, 2000, 26 (07) :805-808

[2] Bone marrow transplantation for Epstein-Barr virus-related clonal T cell proliferation associated with hemophagocytosis [J].

Imashuku, S ;

Naya, M ;

Yamori, M ;

Nakabayashi, Y ;

Hojo, M ;

Kihara, A ;

Tabata, Y ;

Akioka, C ;

Hibi, S ;

Todo, S .

BONE MARROW TRANSPLANTATION, 1997, 19 (10) :1059-1060

[3] GANCICLOVIR FOR CHRONIC ACTIVE EPSTEIN-BARR-VIRUS INFECTION [J].

ISHIDA, Y ;

YOKOTA, Y ;

TAUCHI, H ;

FUKUDA, M ;

TAKAOKA, T ;

HAYASHI, M ;

MATSUDA, H .

LANCET, 1993, 341 (8844) :560-561

[4]

KEISEI KH, 1987, LANCET, V1, P154

[5] Quantitative analysis of Epstein-Barr virus load by using a real-time PCR assay [J].

Kimura, H ;

Morita, M ;

Yabuta, Y ;

Kuzushima, K ;

Kato, K ;

Kojima, S ;

Matsuyama, T ;

Morishima, T .

JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (01) :132-136

[6] Establishment of anbi-Epstein-Barr virus (EBV) cellular immunity by adoptive transfer of virus-specific cytotoxic T lymphocytes from an HLA-matched sibling to a patient with severe chronic active EBV infection [J].

Kuzushima, K ;

Yamamoto, M ;

Kimura, H ;

Ando, Y ;

Kudo, T ;

Tsuge, I ;

Morishima, T .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1996, 103 (02) :192-198

[7] CHRONIC, SYMPTOMATIC EPSTEIN-BARR VIRUS-INFECTIONS [J].

RICKINSON, AB .

IMMUNOLOGY TODAY, 1986, 7 (01) :13-14

[8] Interferon-α therapy for chronic active Epstein-Barr virus infection:: Potential effect on the development of T-lymphoproliferative disease [J].

Sakai, Y ;

Ohga, S ;

Tonegawa, Y ;

Takada, H ;

Nakao, F ;

Nakayama, H ;

Aoki, T ;

Yamamori, S ;

Hara, T .

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 1998, 20 (04) :342-346

[9] CLINICOPATHOLOGICAL SPECTRUM OF EPSTEIN-BARR VIRUS-ASSOCIATED T-CELL MALIGNANCIES [J].

SU, IJ ;

HSIEH, HC .

LEUKEMIA & LYMPHOMA, 1992, 7 (1-2) :47-53

[10] Successful treatment of Epstein-Barr virus-associated natural killer cell large granular lymphocytic leukaemia using allogeneic peripheral blood stem cell transplantation [J].

Takami, A ;

Nakao, S ;

Yachie, A ;

Kasahara, Y ;

Okumura, H ;

Miura, Y ;

Sugimori, N ;

Zeng, W ;

Wang, H ;

Kotani, T ;

Shiobara, S ;

Matsuda, T .

BONE MARROW TRANSPLANTATION, 1998, 21 (12) :1279-1282