Into the wild: simian immunodeficiency virus (SIV) infection in natural hosts

被引：119

作者：

Pandrea, Ivona ^{[1
,2
]}

Sodora, Donald L. ^{[3
]}

Silvestri, Guido ^{[4
]}

Apetrei, Cristian ^{[1
,5
]}

机构：

[1] Tulane Natl Primate Res Ctr, Covington, LA 70433 USA

[2] Tulane Univ, Sch Med, Dept Pathol, New Orleans, LA 70112 USA

[3] Seattle Biomed Res Inst, Seattle, WA 98109 USA

[4] Univ Penn, Sch Med, Dept Pathol, Philadelphia, PA 19107 USA

[5] Tulane Univ, Sch Publ Hlth, Dept Trop Med, New Orleans, LA 70112 USA

来源：

TRENDS IN IMMUNOLOGY | 2008年 / 29卷 / 09期

关键词：

D O I：

10.1016/j.it.2008.05.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Identifying distinctions between pathogenic HIV and simian immunodeficiency virus (SIV) infections and non-progressive SIV in natural African primate hosts might provide key insights into HIV pathogenesis. Similar to pathogenic HIV infection in humans, natural SIV infections result in high viral replication and massive acute depletion of mucosal CD4(+) T cells. A key distinction of natural SIV infections is a rapidly developing anti-inflammatory milieu that prevents chronic activation, apoptosis and proliferation of T cells and preserves the function of other immune cell subsets, thus contributing to the integrity of the mucosal barrier and the lack of microbial translocation from the gut to the peritoneum. Immunologic features observed during natural SIV infections suggest approaches for designing new strategies for producing novel second-generation vaccines and therapeutic approaches to inhibit disease progression in HIV-infected humans.

引用

页码：419 / 428

页数：10

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