Prevalence of Neisseria meningitidis carriers in the school population of Catalonia, Spain

被引:22
作者
Domínguez, A
Cardeñosa, N
Izquierdo, C
Sánchez, F
Margall, N
Vázquez, JA
Salleras, L
机构
[1] Generalitat Catalunya, Direccio Gen Salut Publ, Barcelona 08028, Spain
[2] Hosp Santa Creu & Sant Pau, Dept Microbiol, Barcelona, Spain
[3] Inst Salud Carlos III, CNMVIS, Reference Lab Neisseria, Madrid, Spain
关键词
D O I
10.1017/S0950268801006173
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The aim of this study was to determine the prevalence of healthy Neisseria meningitidis pharyngeal carriers in a representative sample of the Catalonian school population, as well as its associated factors. The sample was divided into age groups: less than or equal to 5, 6-7 and 13-14 years old. Parents were given a questionnaire to collect information on sociodemographic and epidemiological variables. Oropharyngeal swabs were collected with a cotton-tipped swab in an Amies transport medium and cultured on Thayer Martin plates at 35 degreesC in 5% CO2. The isolates were serogrouped and sero/subtyped. Of the 1406 children studied, 75 (5.34%) meningococcal carriers were detected: 63 B (4.5%), 9 non groupable (0.7%), 2 29E (0.1%) and 1X (0.07%). No serogroup C meningococci were found in this study, probably due to the high A+C vaccination coverage of up to 68.9% in children 6-7 years old. Bivariate analysis identified six statistically significant risk factors for meningococcal carriage: increasing age, recent upper respiratory tract infection, previous antibiotic treatment, number of students in the class, size of the classroom and social class. Multivariate analysis found that only age and previous antibiotic treatment remained statistically significant when the other factors were controlled.
引用
收藏
页码:425 / 433
页数:9
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