E protein function in lymphocyte development

被引：158

作者：

Quong, MW ^{[1
]}

Romanow, WJ ^{[1
]}

Murre, C ^{[1
]}

机构：

[1] Univ Calif San Diego, Div Biol, La Jolla, CA 92093 USA

来源：

ANNUAL REVIEW OF IMMUNOLOGY | 2002年 / 20卷

关键词：

E2A; Id; thymocyte; B lymphocyte; helix-loop-helix (HLH);

D O I：

10.1146/annurev.immunol.20.092501.162048

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lymphocytes arise from hematopoietic stem cells through the coordinated action of transcription factors. The E proteins (E12, E47, HEB and E2-2) have emerged as key regulators of both B and T lymphocyte differentiation. This review summarizes the current data and examines the various functions of E proteins and their antagonists, Id2 and Id3, throughout lymphoid maturation. Beyond an established role in B and T lineage commitment, E proteins continue to be essential at subsequent stages of development. E protein activity regulates the expression of surrogate and antigen receptor genes, promotes Ig and TCR rearrangements, and coordinates cell survival and proliferation with developmental progression in response to TCR signaling. Finally, this review also discusses the role of E47 as a tumor suppressor.

引用

页码：301 / 322

页数：22

共 124 条

[1] THYMIC TUMORIGENESIS INDUCED BY OVEREXPRESSION OF P56LCK [J].

ABRAHAM, KM ;

LEVIN, SD ;

MARTH, JD ;

FORBUSH, KA ;

PERLMUTTER, RM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (09) :3977-3981

[2] SELECTIVE REQUIREMENT FOR MAP KINASE ACTIVATION IN THYMOCYTE DIFFERENTIATION [J].

ALBEROLAILA, J ;

FORBUSH, KA ;

SEGER, R ;

KREBS, EG ;

PERLMUTTER, RM .

NATURE, 1995, 373 (6515) :620-623

[3]

[Anonymous], TRANSCRIPTIONAL REGU

[4] THE E2A GENE-PRODUCT CONTAINS 2 SEPARABLE AND FUNCTIONALLY DISTINCT TRANSCRIPTION ACTIVATION DOMAINS [J].

ARONHEIM, A ;

SHIRAN, R ;

ROSEN, A ;

WALKER, MD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (17) :8063-8067

[5] Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47 [J].

Bain, G ;

Quong, MW ;

Soloff, RS ;

Hedrick, SM ;

Murre, C .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (11) :1605-1616

[6] Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade [J].

Bain, G ;

Cravatt, CB ;

Loomans, C ;

Alberola-Ila, J ;

Hedrick, SM ;

Murre, C .

NATURE IMMUNOLOGY, 2001, 2 (02) :165-171

[7] Both E12 and E47 allow commitment to the B cell lineage [J].

Bain, G ;

Maandag, ECR ;

Riele, HPJT ;

Feeney, AJ ;

Sheehy, A ;

Schlissel, M ;

Shinton, SA ;

Hardy, RR ;

Murre, C .

IMMUNITY, 1997, 6 (02) :145-154

[8] Positive and negative regulation of V(D)J recombination by the E2A proteins [J].

Bain, G ;

Romanow, WJ ;

Albers, K ;

Havran, WL ;

Murre, C .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (02) :289-300

[9] E2A deficiency leads to abnormalities in alpha beta T-cell development and to rapid development of T-cell lymphomas [J].

Bain, G ;

Enel, I ;

Maandag, ECR ;

teRiele, HPJ ;

Voland, JR ;

Sharp, LL ;

Chun, J ;

Huey, B ;

Pinkel, D ;

Murre, C .

MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (08) :4782-4791

[10] E2A PROTEINS ARE REQUIRED FOR PROPER B-CELL DEVELOPMENT AND INITIATION OF IMMUNOGLOBULIN GENE REARRANGEMENTS [J].

BAIN, G ;

MAANDAG, ECR ;

IZON, DJ ;

AMSEN, D ;

KRUISBEEK, AM ;

WEINTRAUB, BC ;

KROP, I ;

SCHLISSEL, MS ;

FEENEY, AJ ;

VANROON, M ;

VANDERVALK, M ;

TERIELE, HPJ ;

BERNS, A ;

MURRE, C .

CELL, 1994, 79 (05) :885-892

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