E protein function in lymphocyte development

被引：158

作者：

Quong, MW ^{[1
]}

Romanow, WJ ^{[1
]}

Murre, C ^{[1
]}

机构：

[1] Univ Calif San Diego, Div Biol, La Jolla, CA 92093 USA

来源：

ANNUAL REVIEW OF IMMUNOLOGY | 2002年 / 20卷

关键词：

E2A; Id; thymocyte; B lymphocyte; helix-loop-helix (HLH);

D O I：

10.1146/annurev.immunol.20.092501.162048

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lymphocytes arise from hematopoietic stem cells through the coordinated action of transcription factors. The E proteins (E12, E47, HEB and E2-2) have emerged as key regulators of both B and T lymphocyte differentiation. This review summarizes the current data and examines the various functions of E proteins and their antagonists, Id2 and Id3, throughout lymphoid maturation. Beyond an established role in B and T lineage commitment, E proteins continue to be essential at subsequent stages of development. E protein activity regulates the expression of surrogate and antigen receptor genes, promotes Ig and TCR rearrangements, and coordinates cell survival and proliferation with developmental progression in response to TCR signaling. Finally, this review also discusses the role of E47 as a tumor suppressor.

引用

页码：301 / 322

页数：22

共 124 条

[11] E2A AND E2-2 ARE SUBUNITS OF B-CELL-SPECIFIC E2-BOX DNA-BINDING PROTEINS [J].

BAIN, G ;

GRUENWALD, S ;

MURRE, C .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (06) :3522-3529

[12]

Barndt R, 1999, J IMMUNOL, V163, P3331

[13] Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB [J].

Barndt, RJ ;

Dai, MF ;

Zhuang, Y .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (18) :6677-6685

[14] THE PROTEIN ID - A NEGATIVE REGULATOR OF HELIX-LOOP-HELIX DNA-BINDING PROTEINS [J].

BENEZRA, R ;

DAVIS, RL ;

LOCKSHON, D ;

TURNER, DL ;

WEINTRAUB, H .

CELL, 1990, 61 (01) :49-59

[15] Disruption of αβ but not of γδ T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors [J].

Blom, B ;

Heemskerk, MHM ;

Verschuren, MCM ;

van Dongen, JJM ;

Stegmann, APA ;

Bakker, AQ ;

Couwenberg, F ;

Res, PCM ;

Spits, H .

EMBO JOURNAL, 1999, 18 (10) :2793-2802

[16] Lineage commitment and differentiation of T and natural killer lymphocytes in the fetal mouse [J].

Carlyle, JR ;

Zuniga-Pflucker, JC .

IMMUNOLOGICAL REVIEWS, 1998, 165 :63-74

[17] E47 activates the Ig-heavy chain and TdT loci in non-B cells [J].

Choi, JK ;

Shen, CP ;

Radomska, HS ;

Eckhardt, LA ;

Kadesch, T .

EMBO JOURNAL, 1996, 15 (18) :5014-5021

[18] AN ID-RELATED HELIX LOOP HELIX PROTEIN ENCODED BY A GROWTH FACTOR-INDUCIBLE GENE [J].

CHRISTY, BA ;

SANDERS, LK ;

LAU, LF ;

COPELAND, NG ;

JENKINS, NA ;

NATHANS, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (05) :1815-1819

[19] Identification of the E2A gene products as regulatory targets of the G1 cyclin-dependent kinases [J].

Chu, C ;

Kohtz, DS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (11) :8524-8534

[20] The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte [J].

Crompton, T ;

Gilmour, KC ;

Owen, MJ .

CELL, 1996, 86 (02) :243-251

← 1 2 3 4 5 6 7 8 9 10 →