Nitric oxide metabolites in CSF of patients with MS are related to clinical disease course

被引：33

作者：

Svenningsson, A

Petersson, AS

Andersen, O

Hansson, GK

机构：

[1] Karolinska Hosp, Neuroimmunol Unit, Ctr Mol Med, Dept Med, S-17176 Stockholm, Sweden

[2] Karolinska Hosp, Dept Clin Neurosci, S-17176 Stockholm, Sweden

[3] Sahlgrens Univ Hosp, Dept Clin Physiol, S-41345 Gothenburg, Sweden

[4] Sahlgrens Univ Hosp, Dept Clin Neurosci, S-41345 Gothenburg, Sweden

来源：

NEUROLOGY | 1999年 / 53卷 / 08期

关键词：

MS; meningitis; nitric oxide; CSF;

D O I：

10.1212/WNL.53.8.1880

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In this study, we have analyzed the stable metabolites of nitric oxide (NO), nitrite and nitrate, in the CSF of patients with MS, lymphocytic meningitis, and in healthy control subjects. Patients with MS with an active disease course exhibited increased CSF nitrite levels compared with patients with stable MS and healthy control subjects, whereas CSF nitrate levels did not differ between these groups. High CSF levels of both metabolites were seen in patients with meningitis, These data indicate that CSF nitrite levels may reflect clinical disease activity in MS.

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页码：1880 / 1882

页数：3

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