Nitric oxide: A potential mediator of retinal ganglion cell damage in glaucoma

被引：161

作者：

Neufeld, AH ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USA

来源：

SURVEY OF OPHTHALMOLOGY | 1999年 / 43卷

关键词：

glaucoma; nitric oxide synthase; optic nerve; rat;

D O I：

10.1016/S0039-6257(99)00010-7

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

In the glaucomatous optic nerve head, excessive nitric oxide (NO) may be responsible, at least in part, for degeneration of axons of retinal ganglion cells. We have demonstrated the apparent up-regulation and induction of certain isoforms of nitric oxide synthase (NOS), the enzyme that synthesizes NO, in astrocytes in the prelaminar and lamina cribrosa regions of optic nerve heads of patients with glaucoma. Evidence of NO toxicity, histochemical staining for nitrotyrosine, is present in these damaged optic nerve heads. In rats with experimentally induced, moderately elevated intraocular pressure, the isoforms of NOS were also identified. (C) 1999 by Elsevier Science Inc. All rights reserved.

引用

页码：S129 / S135

页数：7

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