PGC-1 Proteins and Heart Failure

被引：115

作者：

Riehle, Christian ^{[1
]}

Abel, E. Dale ^{[1
]}

机构：

[1] Univ Utah, Sch Med, Div Endocrinol Metab & Diabet, Program Mol Med, Salt Lake City, UT 84112 USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2012年 / 22卷 / 04期

关键词：

TRANSCRIPTIONAL COACTIVATOR PGC-1-ALPHA; FATTY-ACID OXIDATION; MITOCHONDRIAL BIOGENESIS; PRESSURE-OVERLOAD; CARDIAC-HYPERTROPHY; GAMMA COACTIVATOR-1; GENE-EXPRESSION; ADAPTIVE THERMOGENESIS; INDUCIBLE COACTIVATOR; SYSTOLIC OVERLOAD;

D O I：

10.1016/j.tcm.2012.07.003

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The transcriptional coactivators PGC-1 alpha and PGC-1 beta are master regulators of oxidative phosphorylation and fatty acid oxidation gene expression. Pressure overload hypertrophy and heart failure are associated with repressed PGC-1 alpha and PGC-1 beta gene expression. Maintaining expression of PGC-1 alpha and -beta preserves contractile function in response to a pathological increase in workload. Here, we discuss the regulation of PGC-1 proteins under conditions of pressure overload hypertrophy and heart failure. (Trends Cardiovasc Med 2012;22:98-105) (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：98 / 105

页数：8

共 54 条

[1]

Mitochondrial adaptations to physiological vs. pathological cardiac hypertrophy [J].

Abel, E. Dale ;

Doenst, Torsten .

CARDIOVASCULAR RESEARCH, 2011, 90 (02) :234-242

[2]

Andersson, U ;

Scarpulla, RC .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (11) :3738-3749

[3]

Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle [J].

Arany, Z ;

He, HM ;

Lin, JD ;

Hoyer, K ;

Handschin, C ;

Toka, O ;

Ahmad, F ;

Matsui, T ;

Chin, S ;

Wu, PH ;

Rybkin, II ;

Shelton, JM ;

Manieri, M ;

Cinti, S ;

Schoen, FJ ;

Bassel-Duby, R ;

Rosenzweig, A ;

Ingwall, JS ;

Spiegelman, BM .

CELL METABOLISM, 2005, 1 (04) :259-271

[4]

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α [J].

Arany, Zoltan ;

Foo, Shi-Yin ;

Ma, Yanhong ;

Ruas, Jorge L. ;

Bommi-Reddy, Archana ;

Girnun, Geoffrey ;

Cooper, Marcus ;

Laznik, Dina ;

Chinsomboon, Jessica ;

Rangwala, Shamina M. ;

Baek, Kwan Hyuck ;

Rosenzweig, Anthony ;

Spiegelman, Bruce M. .

NATURE, 2008, 451 (7181) :1008-U8

[5]

Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-γ coactivator 1α [J].

Arany, Zoltan ;

Novikov, Mikhail ;

Chin, Sherry ;

Ma, Yanhong ;

Rosenzweig, Anthony ;

Spiegelman, Bruce M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (26) :10086-10091

[6]

Transcriptional effects of chronic Akt activation in the heart [J].

Cook, SA ;

Matsui, T ;

Li, L ;

Rosenzweig, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (25) :22528-22533

[7]

Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy [J].

Dávila-Román, VG ;

Vedala, G ;

Herrero, P ;

de las Fuentes, L ;

Rogers, JG ;

Kelly, DP ;

Gropler, RJ .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 40 (02) :271-277

[8]

Decreased rates of substrate oxidation ex vivo predict the onset of heart failure and contractile dysfunction in rats with pressure overload [J].

Doenst, Torsten ;

Pytel, Gracjan ;

Schrepper, Andrea ;

Amorim, Paulo ;

Faerber, Gloria ;

Shingu, Yasushige ;

Mohr, Friedrich W. ;

Schwarzer, Michael .

CARDIOVASCULAR RESEARCH, 2010, 86 (03) :461-470

[9]

Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-α/PGC-1α gene regulatory pathway [J].

Duncan, Jennifer G. ;

Fong, Juliet L. ;

Medeiros, Denis M. ;

Finck, Brian N. ;

Kelly, Daniel P. .

CIRCULATION, 2007, 115 (07) :909-917

[10]

Peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease [J].

Finck, Brian N. ;

Kelly, Daniel P. .

CIRCULATION, 2007, 115 (19) :2540-2548

← 1 2 3 4 5 6 →