Anaemia of acute malaria infections in non-immune patients primarily results from destruction of uninfected erythrocytes

被引：174

作者：

Jakeman, GN

Saul, A ^{[1
]}

Hogarth, WL

Collins, WE

机构：

[1] Univ Queensland, Royal Brisbane Hosp, Queensland Inst Med Res, Herston, Qld 4029, Australia

[2] Griffith Univ, Sch Appl Math & Stat, Nathan, Qld 4111, Australia

[3] Queensland Inst Med Res, Herston, Qld 4029, Australia

[4] Griffith Univ, Australian Sch Environm Studies, Nathan, Qld 4111, Australia

[5] Ctr Dis Control & Prevent, Div Parasit Dis, Chamblee, GA 30341 USA

来源：

PARASITOLOGY | 1999年 / 119卷

关键词：

anaemia; malaria; merozoite; modelling; Plasmodium falciparum;

D O I：

10.1017/S0031182099004564

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

While anaemia has long been recognized as a consequence of acute infections with malaria, the relative contributions of direct erythrocyte destruction by parasites, destruction of uninfected erythrocytes and changes in erythropoiesis have been unclear. Fitting of parasitaemia and anaemia data from neurosyphilis patients undergoing malaria therapy to a mathematical model shows that in these patients, an average of 8.5 erythrocytes were destroyed in addition to each erythrocyte observed to become parasitized. The model also showed that dyserythropoiesis plays an insignificant role in the resulting anaemia. The anaemia occurs before a substantial antibody response to parasites or erythrocytes could be generated. We postulate that uninfected erythrocyte destruction occurs through phagocytosis of erythrocytes bound to merozoites killed as a result of the accompanying malaria paroxysms.

引用

页码：127 / 133

页数：7

共 21 条

[1] NON-LINEAR PHENOMENA IN HOST-PARASITE INTERACTIONS [J].