Beyond threat: Amygdala reactivity across multiple expressions of facial affect

被引:325
作者
Fitzgerald, Daniel A.
Angstadt, Mike
Jelsone, Laura M.
Nathan, Pradeep J.
Phan, K. Luan
机构
[1] Univ Chicago, Dept Psychiat, Chicago, IL 60637 USA
[2] Univ S Carolina, Dept Psychol, Columbia, SC 29208 USA
[3] Monash Univ, Dept Physiol, Monash Ctr Brain & Behav, Clayton, Vic 3168, Australia
关键词
fMRI; Amygdala; emotion; faces; fear; threat;
D O I
10.1016/j.neuroimage.2005.11.003
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The amygdala has been consistently isolated as a key neural substrate for processing facial displays of affect. Recent evidence from human lesion and functional neuroimaging studies have begun to challenge the notion that the amygdala is reserved for signals of threat (fear/anger). We performed a 4 T fMRI study in which 20 subjects viewed a contemporary set of photographs displaying 6 different facial expressions (fearful, disgusted, angry, sad, neutral, happy) while performing a task with minimal cognitive demand. Across subjects, the left amygdala was activated by each face condition separately, and its response was not selective for any particular emotion category. These results challenge the notion that the amygdala has a specialized role in processing certain emotions and suggest that the amygdala may have a more general-purpose function in processing salient information from faces. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:1441 / 1448
页数:8
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