Macramolecular crystallography with a third-generation synchrotron source

被引:9
作者
Lindley, PF [1 ]
机构
[1] European Synchrotron Radiat Facil, F-38043 Grenoble, France
来源
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY | 1999年 / 55卷
关键词
D O I
10.1107/S0907444999008288
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The European Synchrotron Radiation Facility (ESRF) at Grenoble, France, is a 6 GeV machine producing hard X-radiation that can be used for pure and applied research in a wide range of disciplines including physics, chemistry, structural biology, materials science, the earth sciences, engineering and medicine. The overall nature of the machine will be described, including the features that give rise to the notation 'third-generation source'. The ESRF is equipped with a number of beamlines which can be used for macromolecular crystallography. Applications include the use of very small crystals, large unit cells, data collection at high resolution, anomalous dispersion measurements for phase determination and time-resolved studies. Key features of these applications will be described.
引用
收藏
页码:1654 / 1662
页数:9
相关论文
共 9 条
[1]   Feasibility and realization of single-pulse laue diffraction on macromolecular crystals at ESRF [J].
Bourgeois, D ;
Ursby, T ;
Wulff, M ;
Pradervand, C ;
Legrand, A ;
Schildkamp, W ;
Laboure, S ;
Srajer, V ;
Teng, TY ;
Roth, M ;
Moffat, K .
JOURNAL OF SYNCHROTRON RADIATION, 1996, 3 :65-74
[2]  
CIPRIANI F, 1997, ESRF NEWSL, V28, P30
[3]  
*ESRF, 1987, BP220 CEDEX, P41
[4]  
*ESRF, 1996, BP220 CEDEX, P69
[5]   Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex [J].
Iwata, S ;
Lee, JW ;
Okada, K ;
Lee, JK ;
Iwata, M ;
Rasmussen, B ;
Link, TA ;
Ramaswamy, S ;
Jap, BK .
SCIENCE, 1998, 281 (5373) :64-71
[6]   X-ray structure of bacteriorhodopsin at 2.5 angstroms from microcrystals grown in lipidic cubic phases [J].
PebayPeyroula, E ;
Rummel, G ;
Rosenbusch, JP ;
Landau, EM .
SCIENCE, 1997, 277 (5332) :1676-1681
[7]   Photolysis of the carbon monoxide complex of myoglobin: Nanosecond time-resolved crystallography [J].
Srajer, V ;
Teng, TY ;
Ursby, T ;
Pradervand, C ;
Ren, Z ;
Adachi, S ;
Schildkamp, W ;
Bourgeois, D ;
Wulff, M ;
Moffat, K .
SCIENCE, 1996, 274 (5293) :1726-1729
[8]  
WATATSUKI S, 1998, J SYNCHROTRON RADIAT, V5, P215
[9]   Crystallographic studies on the ribosome, a large macromolecular assembly exhibiting severe nonisomorphism, extreme beam sensitivity and no internal symmetry [J].
Yonath, A ;
Harms, J ;
Hansen, HAS ;
Bashan, A ;
Schlünzen, F ;
Levin, I ;
Koelln, I ;
Tocilj, A ;
Agmon, I ;
Peretz, M ;
Bartels, H ;
Bennett, WS ;
Krumbholz, S ;
Janell, D ;
Weinstein, S ;
Auerbach, T ;
Avila, H ;
Piolleti, M ;
Morlang, S ;
Franceschi, F .
ACTA CRYSTALLOGRAPHICA SECTION A, 1998, 54 :945-955